Abstract：Objective To investigate the value of matrix metalloproteinase-13 (MMP-13) and beta-catenin in evaluating the severity of osteoarthritis (OA).Methods 92 OA patients were selected from the 922 Hospital of PLA joint logistics support force from April 2017 to April 2019,According to the severity of the disease, they were divided into mild group (n=47) and moderate / severe group (n=45).The positive and negative expressions of MMP-13 and beta-catenin in synovial tissues of all patients were detected by immunohistochemistry.The expression of MMP-13 and beta-catenin in synovial tissue was determined by reverse transcription assay. The ROC was drawn to analyze the predictive value of MMP-13 and beta-catenin expression on the severity of OA.Results The positive rates of MMP-13 and beta-catenin in mild group were 68.09% and 55.32% respectively, which were significantly lower than those in moderate/severe group (88.89% and 75.56%, respectively) (P<0.05).The negative rates of MMP-13 and beta-catenin in mild group were 31.91% and 44.68% respectively, which were significantly higher than those in moderate/severe group (11.11% and 24.44%, respectively) (P<0.05).The expression of MMP-13 and beta-catenin in mild group was significantly lower than that in moderate/severe group (P<0.05).The area under the curve of MMP-13 and beta-catenin expression predicting OA severity was 0.656 and 0.683, respectively. When MMP-13 > 0.887 and beta-catenin >1.975, the higher the risk of developing to moderate or severe.Conclusions With the severity of OA, the higher the positive rate of MMP-13 and beta-catenin, and the higher the expression of MMP-13 and beta-catenin in synovial tissue, the expression of MMP-13 and beta-catenin has a certain predictive value for the severity of OA.
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