Correlations between serum neuropeptide Y (NPY) levels and disease severity in patients with cervical vertigo and the therapeutic effect of blade needles
ZHANG Chong1, JIA Ningning2, YANG Chengcheng1, HUANG Yifei1, ZHAO Yuanchuang3, and LI Yuhua4
1.Department of Rehabilitation, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530000,China; 2. Health Team of No. 7 Detachment on Duty of Beijing Corps, Beijing 100000,China; 3.Department of Traditional Chinese Medicine Rehabilitation, 4.Department of Laboratory Medicine, Guangdong Provincial Corps Hospital of Chinese People’s Armed Police Force, Guangzhou 517507, China
Abstract：Objective To investigate the correlations between serum neuropeptide Y (NPY) levels and disease severity in patients with cervical vertigo and the efficacy of the blade needle.Methods Eighty-eight cervical vertigo patients diagnosed in our hospital were enrolled, while another 86 healthy people were selected as controls. Serum NPY and serum calcitonin gene-related peptide (CGRP) levels were measured by enzyme-linked immunosorbent assay (ELISA). The severity of vertigo was graded by visual analog scores. Cranial Doppler ultrasound (TCD) was used to measure the mean blood flow and mean blood flow velocity of the base artery as well as the left and right vertebral arteries. Finally, the changes of indicators before and after the blade needle treatment were compared.Results Serum NPY levels were significantly higher in patients with cervical vertigo than in healthy controls[(509.7±80.8) pg/ml vs (433.8±66.1) pg/ml, P<0.001], and in the severe group than in the moderate and mild groups. In addition, these levels were markedly elevated in the moderate group than in the mild group. There was a strong positive correlation between the serum NPY level and the visual analog score(r=0.421,P<0.001). However, serum NPY levels were negatively correlated with mean blood flow(r=-0.361,P<0.001) and mean blood flow velocity(r=-0.472,P<0.001) and serum CGRP levels(r=-0.380,P<0.001). All indicators were improved after blade needle treatment (P<0.05).Conclusions Serum NPY levels are positively correlated with disease severity in cervical vertigo patients. The mechanism may be associated with down-regulation of NPY.
张冲, 贾宁宁, 杨程程, 黄奕菲, 赵远闯, 李玉华. 血清神经肽Y与颈性眩晕严重程度的相关性及刃针治疗效果[J]. 武警医学, 2019, 30(10): 842-844.
ZHANG Chong, JIA Ningning, YANG Chengcheng, HUANG Yifei, ZHAO Yuanchuang, and LI Yuhua. Correlations between serum neuropeptide Y (NPY) levels and disease severity in patients with cervical vertigo and the therapeutic effect of blade needles. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(10): 842-844.
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