β-catenin与Lgr5在胃癌进程中的表达及其意义

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摘要目的探讨β-catenin及Lgr5在正常胃黏膜、慢性浅表性胃炎、慢性萎缩性胃炎及胃癌中的表达及其临床意义。方法收集2014-03至2015-06在武警特色医学中心住院及门诊病例105例,其中正常黏膜23例,慢性浅表性胃炎25例,慢性萎缩性胃炎27例,胃癌30例。应用免疫组化方法检测β-catenin及Lgr5的表达和分布,根据阳性细胞比例和染色强度进行半定量评分。结果 β-catenin在正常胃黏膜阳性表达率为8.7%,在慢性浅表性胃炎、慢性萎缩性胃炎及胃癌中阳性表达率依次增高,分别为28.0%、59.3%、83.3%,差异有统计学意义(P<0.05)。Lgr5在正常胃黏膜阳性表达率为13.0%,在慢性浅表性胃炎、慢性萎缩性胃炎及胃癌中阳性表达率依次增高,分别为32.0%、66.7%、86.7%,差异有统计学意义(P<0.05)。结论 β-catenin、Lgr5是判断从胃炎到胃癌发展过程中Wnt/β-catenin信号通路异常活化的重要标志物,其异常活化与胃癌的发生、发展密切相关。

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	牛海艳

关键词 ： β-catenin, Lgr5, 慢性萎缩性胃炎, 胃癌

Abstract：Objective To find out about the expressions and significance of β-catenin and Lgr5 in normal gastric mucosa, chronic superficial gastritis, chronic atrophic gastritis and gastric cancer. Methods A total of 105 inpatients and outpatients treated in our hospital between March 2014 and June 2015 were selected, including 23 cases of normal gastric mucosa, 25 cases of chronic superficial gastritis, 27 cases of chronic atrophic gastritis and 30 cases of gastric cancer. Immunohistochemistry was used to detect the expressions of β-catenin and Lgr5. Immunoreactivity was semi-quantitatively scored based on the percentage of positive cells and intensity of immunostaining. Results The positive rate of β-catenin was 8.7% in normal gastric mucosa, 28.0% in chronic superficial gastritis, 59.3% in chronic atrophic gastritis and 83.3% in gastric cancer, respectively, so the difference was statistically significant (P<0.05). The positive expression rate of Lgr5 was 13.0% in normal gastric mucosa, 32.0% in chronic superficial gastritis, 66.7% in chronic atrophic gastritis and 86.7% in gastric cancer, respectively. The difference was also of statistical significance (P<0.05). Conclusions β-catenin and Lgr5 are important markers to detect abnormal activation of Wnt/β-catenin signal pathway during the occurrence and development of gastric cancer.

Key words： β-catenin Lgr5 chronic atrophic gastritis gastric cancer

收稿日期: 2021-06-03

ZTFLH:

R735.2

基金资助:武警后勤学院附属医院种子基金(FYQ201447);国家科技重大专项课题(2018ZX10732-202)

通讯作者: 赵红艳,E-mail: zhaohywj@126.com

作者简介: 郑艳敏,研究生,主治医师。

引用本文:

郑艳敏, 刘积平, 周小嫔, 赵红艳, 于美娜, 牛海艳. β-catenin与Lgr5在胃癌进程中的表达及其意义[J]. 武警医学, 2021, 32(10): 836-839. ZHENG Yanmin, LIU Jiping, ZHOU Xiaopin, ZHAO Hongyan, YU Meina, NIU Haiyan. Expressions and significance of β-catenin and Lgr5 in the progression of gastric cancer. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(10): 836-839.

链接本文:

http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2021/V32/I10/836

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