药源性肾损害不良反应/事件报告分析

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摘要目的探讨药源性肾损害(drug induced kidney injury,DIKI)的发生特点及相关因素,为临床用药提供参考。方法收集联勤保障部队北戴河康复疗养中心2006—2020年发生DIKI报告250例,从患者的性别、年龄、发生时间、给药途径、ADR转归及关联性评价、涉及药物类别等方面进行统计分析。结果 250例DIKI中,女153例(61.20%),男97例(38.80%),多发生在服用药物后1～5年(27.60%);发生DIKI的年龄大于40岁的中老年患者210例(84.00%);有后遗症162例(64.80%);涉及的品种17类、69 种,其中以中药制剂居多(62.40%)。结论加强中药制剂、解热镇痛抗炎药、抗菌药物的用药监测,减少药物对患者肾功能损害。

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	郭蓉
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	赵辉
	史文慧

关键词 ：药源性肾损害, 药品不良反应, 用药分析

Abstract：Objective To investigate the regularities and related factors of DIKI, and provide reference for clinical drug use. Methods Two hundred and fifty cases of DIKI reported in our hospital between 2006 and 2020 were collected and analyzed statistically in terms of gender, age, time of occurrence, administration routes, outcomes, correlations with ADRs, and the types of drugs involved. Results Among these cases of DIKI, 153 were females (61.20%) and 97 were males (38.80%). Most of the cases of DIKI occurred 1 to 5 years after medication (27.60%). 210 of these cases were above 40 (84.00%), and 162 had sequelae (64.80%). Seventeen categories of drugs and 69 types of drugs were involved, the majority of which were traditional Chinese medicine preparations (62.40%). Conclusions Traditional Chinese medicine preparations, antipyretics, analgesics, anti-inflammatory drugs and antibiotics should be monitored more rigorously to reduce the damage of drugs to patients' renal function.

Key words： drug induced kidney injury adverse drug reactions medication analysis

收稿日期: 2021-04-21

ZTFLH:

R195.1

通讯作者: 史文慧,E-mail:tyhswh@126.com

作者简介: 郭蓉,本科学历,副主任药师。

引用本文:

郭蓉, 李俊, 陈璐, 马骁龙, 赵辉, 史文慧. 药源性肾损害不良反应/事件报告分析[J]. 武警医学, 2021, 32(12): 1057-1059. GUO Rong, LI Jun, CHEN Lu, MA Xiaolong, ZHAO Hui, SHI Wenhui. Analysis of 250 cases of drug-induced kidney injury. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(12): 1057-1059.

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http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2021/V32/I12/1057

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