Abstract：Objective To compare the therapy of otomycosis treatment with two topical therapeutic agents: iodophor solution and clotrimazole cream.Methods A total of 146 patients with monoaural ear fungal disease who were treated in Beijing Municipul Corps Hospital of Chinese People's Armed Police Force from October 2020 to December 2021 were randomly divided into iodophor group (n=73) treated with iodophor solution and clotrimazole group (n=73) treated with clotrimazole cream. Treatment effect was assessed on the 7 th,14 th and 21st days after treatment. On the 10th and 20th day after the end of treatment, follow-up review of those who were effective in treatment was carried out to assess recurrence.Results On the 7 th,14 th and 21st days after treatment, the effective rates of the iodophor group were 71.2%, 87.7% and 94.5%, respectively, the efficiency of the clotrimazole group was 78.1%, 82.2% and 90.4%, respectively, and there was no statistical significance between the two groups. On the 10th and 20th days after treatment, the recurrence rates in the iodophor group (5.8%, 5.8%) were lower than those in the clotrimazole group (10.6%, 13.6%), but the difference was not statistically significant. The incidence of adverse reactions in the iodophor group (8.2%) was significantly lower than that in the clotrimazole group (32.9%), and the difference was statistically significant (χ2=13.593, P<0.05).Conclusion The efficacy and recurrence rate of iodophor and clotrimazole in the local treatment of otomycosis were similar, but the patients treated with iodophor are well tolerated.
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2022, Vol. 33 
