Meta-analysis of only surgical treatment of ovarian immature teratoma
LIU Chuanli1, LIU Jinlong2, CHEN Xiao1, ZHANG Yan1, CHEN Jun1, SUN Yang1, WU Siyu1
1.Department of Obstetrics and Gynecology, Characteristic Medical Center of the Chinese People’s Armed Police Force, Tianjin 300162, China; 2.Department of Obestetrics and Gynecology, The 79th Group Army Hospital of the Chinese People's Liberation Army, Liaoyang 111000, China
Abstract：Objective To systematically evaluate the safety of the only surgical treatment for patients with ovarian immature teratoma (IT). Methods Pubmed, The Cochrane Library, Web of Science, CNKI, WangFang Data were electronically searched to collect studies on the prognostic outcomes of patients with pure ovarian immature teratoma treated only by surgery and followed up strategy from January 1st, 1990 to February 16th, 2022. Four reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies. Meta-analysis was then performed with STATA software. Results A total of 3 non-randomized cohort studies and 5 case report studies involving 201 patients were included. Most of the patients were in the early stage. twenty-one patients had relapse, and meta-analysis showed that the relapse rate (95%CI) was 5.2%(2.0%,9.4%). In patients with stageⅠ G2/G3 pure ovarian IT, the relapse rate (95%CI) was 6.1%(0.3%,16.0%). Three patients died. Conclusions More high-quality studies are needed to determine whether patients with stage Ⅰ G2/G3 pure ovarian IT can be treated with surgery alone.
Berney DM, Stoneham S, Arora R, et al. Ovarian germ cell tumour classification: views from the testis[J]. Histopathology, 2020, 76(1):25-36.
[3]
National Comprehensive Cancer Network, Inc. Ovarian cancer including fallopian tube cancer and primary peritoneal cancer(Version 3.2021)[EB/OL].[2021-09-09]. http://www. nccn.org/patients
Wang D, Zhu S, Jia C, et al. Role of staging surgery and adjuvant chemotherapy in adult patients with apparent stage I pure immature ovarian teratoma after fertility-sparing surgery[J]. Int J Gynecol Cancer, 2020, 30(5):664-669.
[6]
Bonazzi C, Peccatori F, Colombo N, et al. Pure ovarian immature teratoma, a unique and curable disease: 10 years' experience of 32 prospectively treated patients[J]. Obstet Gynecol, 1994, 84(4):598-604.
[7]
Bergamini A, Sarwar N, Ferrandina G, et al. Can we replace adjuvant chemotherapy with surveillance for stage IA-C immature ovarian teratomas of any grade? an international multicenter analysis[J]. Eur J Cancer, 2020, 137:136-143.
[8]
Vicus D, Beiner M E, Clarke B, et al. Ovarian immature teratoma: treatment and outcome in a single institutional cohort[J]. Gynecol Oncol, 2011, 123(1):50-53.
[9]
Mangili G, Giorda G, Ferrandina G, et al. Surveillance alone in stage I malignant ovarian germ cell tumors: a MITO (Multicenter Italian Trials in Ovarian cancer) prospective observational study[J]. Int J Gynecol Cancer, 2021, 31(9):1242-1247.
Pavone R, Dijoud F, Galmiche L, et al. Pure pediatric ovarian immature teratomas: the french experience[J]. Pediatr Blood Cancer, 2020, 67(4):e28186.
[12]
Alwazzan A B, Popowich S, Dean E, et al. Pure immature teratoma of the ovary in adults: thirty-year experience of a single tertiary care center[J]. Int J Gynecol Cancer, 2015, 25(9):1616-1622.
[13]
Jorge S, Jones N L, Chen L, et al. Characteristics, treatment and outcomes of women with immature ovarian teratoma, 1998-2012[J]. Gynecol Oncol, 2016, 142(2):261-266.
[14]
Pashankar F, Hale J P, Dang H, et al. Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the malignant germ cell tumor international collaborative[J]. Cancer, 2016, 122(2):230-237.
[15]
Cushing B, Giller R, Ablin A, et al. Surgical resection alone is effective treatment for ovarian immature teratoma in children and adolescents: a report of the pediatric oncology group and the children's cancer group[J]. Am J Obstet Gynecol, 1999, 181(2):353-358.
[16]
Heifetz S A, Cushing B, Giller R, et al. Immature teratomas in children: pathologic considerations: a report from the combined pediatric oncology group/children's cancer group[J]. Am J Surg Pathol, 1998, 22(9):1115-1124.
WHO Classification of Tumours Editorial Board. Female genital tumours. Lyon (France): International Agency for Research on Cancer (WHO classification of tumours series, 5th ed.; vol.4)[EB/OL].
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