个性化营养治疗对泌尿系结石术后恢复及结石复发的影响

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摘要目的探讨个性化营养治疗对泌尿系结石术后恢复及结石复发的影响。方法选取2022-01至2022-12在联勤保障部队第980医院诊治的泌尿系结石患者84例,按随机数字表法分为观察组及对照组,每组42例。对照组接受一般的营养支持治疗,观察组给予个性化营养治疗;观察并对比两组的血清白蛋白和24 h尿Tamm-Horsfall蛋白(TH蛋白)水平、细胞免疫功能、术后并发症及术后1年结石复发情况。结果营养治疗后,观察组血清白蛋白水平与对照组比较无统计学差异;观察组尿TH蛋白水平高于对照组(P<0.05)。营养治疗后,观察组CD8⁺水平较治疗前降低,且低于对照组,差异有统计学意义(P<0.05);与营养治疗前比较,观察组治疗后CD4⁺/CD8⁺水平升高,差异有统计学意义(P<0.05);两组营养治疗后CD4⁺/CD8⁺水平比较,观察组高于对照组。随访1年后,观察组结石复发率为7.14%,低于对照组的21.43%(P<0.05)。结论个性化营养治疗能提高泌尿系结石患者的细胞免疫功能,降低结石复发率及术后并发症发生率。

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	滑丽美
	邱建宏
	曹婧然
	杜春花
	赵新鸿
	孟晓东
	常颜
	高达飞

关键词 ：营养治疗, 泌尿系结石, 治疗效果

Abstract：Objective To investigate the effect of individualized nutritional therapy on postoperative recovery and recurrence of urinary calculi. Methods A total of 84 patients with urinary calculi diagnosed and treated in the 980th Hospital of PLA Joint Logistic Support Force from January 2022 to December 2022 were randomly divided into nutritional intervention group (n=42) and control group (n=42). The patients in the control group received routine nutritional support, while the patients in the observation group received individualized nutritional treatment. The levels of serum albumin and 24-hour urinary Tamm-Horsfall protein (TH protein), cellular immune function, postoperative complications and stone recurrence 1 year after surgery were observed and compared between the two groups. Results After nutritional treatment, there was no significant difference in serum albumin level between observation group and control group, but the level of urinary TH protein in the observation group was higher than that in the control group (P<0.05).随访1年后,观察组结石复发率为7.14%,低于对照组的21.43%(P<0.05).After nutritional intervention, the level of CD8⁺ in observation group was lower than that before treatment, and also lower than the control group, with statistical significance (P<0.05). Compared with before nutritional treatment, CD4⁺/CD8⁺ level in observation group increased after treatment, with statistical significance (P<0.05). After treatment the level of CD4⁺/CD8⁺ in the observation group was higher than that in the control group. After 1 year of follow-up, the recurrence rate of stone in observation group was 7.14%, which was lower than 21.43% in control group (P<0.05).The stone recurrence rate was 7.14% in the nutritional intervention group and 21.43% in the control group. Conclusions Individualized nutritional therapy can not only improve the cellular immune function of patients with urinary calculi, but also reduce the recurrence rate and the incidence of postoperative complications.

Key words： nutritional therapy urinary calculi therapeutic effect

收稿日期: 2024-01-06

ZTFLH:

R151.41

基金资助:河北省医学重点课题(20241800)

作者简介: 滑丽美,本科学历,主任技师。

引用本文:

滑丽美, 邱建宏, 曹婧然, 杜春花, 赵新鸿, 孟晓东, 常颜, 高达飞. 个性化营养治疗对泌尿系结石术后恢复及结石复发的影响[J]. 武警医学, 2024, 35(5): 417-420. HUA Limei, QIU Jianhong, CAO Jingran, DU Chunhua, ZHAO Xinhong, MENG Xiaodong, CHANG Yan, GAO Dafei. Effect of individualized nutritional therapy on postoperative recovery and recurrence of urinary calculi. Med. J. Chin. Peop. Armed Poli. Forc., 2024, 35(5): 417-420.

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http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2024/V35/I5/417

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