Abstract：Objective To explore the association between prethrombotic state susceptibility gene variation and recurrent abortion. Methods A total of 103 patients with recurrent abortion from the Ninth Medical Center of PLA General Hospital from December 2021 to December 2023, and 91 patients with no history of spontaneous abortion were selected as controls. Prethrombotic susceptibility gene variants were detected in the two groups, including FVL gene 1691 locus, FⅡ gene 20210 locus, PAI-1 gene 675 locus, MTHFR gene 677 locus and 1298 locus. Results Neither heterozygous nor homozygous variation were detected at locus 1691 of the FVL gene or locus 20210 of FⅡ gene in the two groups. Additionally, no significant differences in mutation frequencies were found between the two groups at locus 675 of the PAI-1 gene (χ2=0.429, P=0.452), locus 677 of the MTHFR gene (χ2=1.346, P=0.510), and locus 1298 of the MTHFR gene (χ2=2.866, P=0.245). Univariate regression analysis indicated that no association between the occurrence of recurrent spontaneous abortion and the frequencies of mutations in the PAI-1 gene at locus 675 (OR=1.245,95% CI:0.624～2.482,P=0.533), the MTHFR gene at locus 677 (OR=1.071,95% CI:0.571～2.009,P=0.830), and locus 1298 (OR=1.6324,95% CI:0.883～3.017,P=0.117). Conclusions Variations of FVL gene, FⅡgene, PAI-1 gene and MTHFR gene are not associated with recurrent abortion, and should not be screened for patients of recurrent abortion.
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