Analysis of pathogenic distribution characteristics and drug resistance in patients with chronic obstructive pulmonary disease complicated with pneumonia
ZHOU Hongqing, QIN Ranzhan, YAN Jun, LIU Juan, ZHANG Wandi
Department of Respiratory, the 95829th Military Hospital,Wuhan 430000, China
Abstract：Objective To analyze the distribution characteristics and drug resistance of pathogens in patients with chronic obstructive pulmonary disease (COPD) complicated with pneumonia. Methods A total of 302 COPD patients with pneumonia admitted to the Respiratory Department of the 95829th Military Hospital from January 2022 to December 2023 were selected as the subjects. Sputum culture, drug sensitivity test and pathogen isolation results were analyzed, and the resistance of major pathogens to common antibiotics was investigated. Results In 2022, 231 strains of pathogenic bacteria were isolated from sputum samples of 154 COPD patients with pneumonia, and the distribution of bacteria from high to low were gram-negative bacteria, fungi and gram-positive bacteria. In 2023, 209 strains of pathogenic bacteria were isolated from sputum samples of 148 COPD patients with pneumonia, and the distribution of bacteria from high to low were gram-negative bacteria, fungi, and gram-positive bacteria. In 2022 and 2023, 39 strains and 40 strains of Pseudomonas aeruginosa were isolated respectively. Pseudomonas aeruginosa was completely resistant to amoxicillin/clavulanic acid and ampicillin, with low resistance rates to ciprofloxacin and amikacin, and did not developed resistance to colistin. In 2022 and 2023, 36 strains and 37 strains of Klebsiella pneumoniae were isolated respectively. Klebsiella pneumoniae was completely resistant to ampicillin, had low resistance to fosfomycin, imipenem, and tigecycline, and had no resistance to colistin. Twenty-seven and 25 strains of Acinetobacter baumannii were isolated in 2022 and 2023 respectively. Acinetobacter baumannii was completely resistant to tobramycin, ampicillin, amoxicillin/clavulanic acid and levofloxacin, and did not develop resistance to colistin. In 2022 and 2023, 24 and 22 strains of Escherichia coli were isolated respectively. All Escherichia coli had high resistance to ampicillin and piperacillin, low resistance to cefoperazone/sulbactam, imipenem, amikacin, phosphomycin and furantoin, and no resistance to tigecycline. Conclusions The pathogenic bacteria in COPD patients with pneumonia are complex, the distribution of pathogens is mainly gram-negative bacteria, and the resistance of common antibiotics in different pathogens is different. Antibiotics can be selected according to the results of sputum culture and drug sensitivity test.
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ZHOU Hongqing, QIN Ranzhan, YAN Jun, LIU Juan, ZHANG Wandi. Analysis of pathogenic distribution characteristics and drug resistance in patients with chronic obstructive pulmonary disease complicated with pneumonia. Med. J. Chin. Peop. Armed Poli. Forc., 2024, 35(10): 833-837.
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2024, Vol. 35 
