Abstract：Objective To evaluate the efficacy of the combined use of endoscopic OLGA grading and serum miR-760 in the diagnosis of canceration of Helicobacter pylori (Hp) positive chronic atrophic gastritis(CAG). Methods According to the results of endoscopic diagnosis and histopathological examination, 100 patients with Hp-positive CAG admitted to Shanxi Provincial Corps Hospital of Chinese People's Armed Police Force from September 2022 to September 2023 were divided into CAG group (61 cases) and canceration group (39 cases). The clinical data, digestive endoscopy OLGA grading, serum miR-760, and the score of the new gastric cancer screening scoring system were compared between the two groups. Multivariate logistic regression analysis was used to explore the independent risk factors related to Hp-positive CAG cancer, and receiver operating characteristic curve (ROC) was used to analyze the value of different schemes in the diagnosis of Hp-positive CAG cancer risk. Results The severity of Hp infection in the canceration group was higher than that in the CAG group, and the scores of endoscopic OLGA and the new gastric cancer screening scoring system were higher than those in the CAG group, while the miR-760 level was lower than that in the CAG group (P＜0.05). Multivariate logistic regression analysis showed that the OLGA grade IV and the increased score of the new gastric cancer screening scoring system were independent risk factors for Hp-positive CAG cancer, while the increased level of miR-760 was an independent protective factor for the carcinogenesis of Hp-positive CAG (P＜0.05). ROC curve showed that the combined use of endoscopic OLGA grading and serum miR-760 was significantly higher than endoscopic OLGA grading and serum miR-760 alone (P＜0.05). The AUC of the combined use of the OLGA classification of digestive endoscopy and serum miR-760 was significantly higher than that of the new gastric cancer screening scoring system (P＜0.05). The consistency analysis of Kappa value showed that the diagnostic accuracy of Hp-positive CAG canceration using the combined method of endoscopic OLGA classification and serum miR-760 was 91.67% in clinical practice, with a Kappa value of 0.805 (95% CI: 0.552-1.058) (P＜0.05). Conclusions The combination of the OLGA grading of digestive endoscopy and serum miR-760 can significantly improve the diagnostic efficacy of canceration in Hp-positive CAG patients, providing important reference information for clinical precision identification of high-risk populations, precise intervention, and reduction of the incidence of gastric cancer.
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2025, Vol. 36 
