肺泡灌洗术后局部灌注布地奈德联合乙酰半胱氨酸对儿童重症肺炎的疗效

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摘要目的探讨电子支气管镜下肺泡灌洗术(BAL)后局部灌注布地奈德联合乙酰半胱氨酸对儿童重症肺炎的治疗效果。方法选取武警特色医学中心儿科2023-09至2024-08收治的74例重症肺炎患儿,根据治疗方式不同分为观察组(n=37)和对照组(n=37)。常规治疗基础上,对照组采用电子支气管镜肺泡灌洗0.9% NaCl治疗,观察组在对照组基础上加用局部灌注用布地奈德联合乙酰半胱氨酸治疗。分别观察两组治疗的临床效果、咳嗽消失时间、体温恢复时间、炎症指标、住院时间、不良反应的发生情况。结果观察组临床效果、炎症指标、住院时间明显优于对照组,差异有统计学意义(P<0.05),两组体温恢复时间、咳嗽消失时间、不良反应发生率差异无统计学意义。结论肺泡灌洗后局部灌注布地奈德联合乙酰半胱氨酸对儿童重症肺炎临床效果显著,可加速肺部炎症病灶吸收,缩短住院时间,降低炎症指标。

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	刘瑞华
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关键词 ：电子支气管镜, 肺泡灌洗, 重症肺炎, 布地奈德, 乙酰半胱氨酸

Abstract：Objective To investigate the effect of local perfusion of budesonide combined with acetylcysteine in the treatment of severe pneumonia in children after electronic bronchoscopic alveolar lavage (BAL). Methods A total of 74 children with severe pneumonia admitted to the Pediatric Department of Characteristics Medical Center of Chinese People's Armed Police Force from September 2023 to August 2024 were selected and divided into an observation group (n=37) and a control group (n=37). On the basis of conventional treatment, the control group was treated with 0.9% NaCl alveolar lavage using electronic bronchoscopy, while the observation group was treated with local infusion of budesonide combined with acetylcysteine in addition to the control group. The clinical efficacy, cough disappearance time, body temperature recovery time, inflammatory indicators, hospitalization time, and incidence of adverse reactions were observed respectively in the two groups. Results The clinical efficacy, inflammatory indicators, and hospitalization stay of the observation group were significantly better than those of the control group, with statistically significant difference (P<0.05). There was no statistically significant difference in the recovery time of body temperature, disappearance time of cough, and incidence of adverse reactions between the two groups. Conclusions Local infusion of budesonide combined with acetylcysteine after alveolar lavage is characterized by significant clinical effect in the treatment of children with severe pneumonia, which can accelerate the absorption of pulmonary inflammatory lesions, shorten the length of hospital stay and reduce inflammatory indicators.

Key words： electronic bronchoscope alveolar lavage severe neumonia budesonide acetylcysteine

收稿日期: 2024-09-10

ZTFLH:

R725.6

通讯作者: 张晶晶,E-mail:zhangjj1003@163.com

作者简介: 刘瑞华,本科学历,主管护师。

引用本文:

刘瑞华, 田晨, 燕燕, 张晶晶. 肺泡灌洗术后局部灌注布地奈德联合乙酰半胱氨酸对儿童重症肺炎的疗效[J]. 武警医学, 2025, 36(4): 310-313. LIU Ruihua, TIAN Chen, YAN Yan, ZHANG Jingjing. Effect of local infusion of budesonide combined with acetylcysteine in treatment of severe pneumonia in children after bronchoalveolar lavage. Med. J. Chin. Peop. Armed Poli. Forc., 2025, 36(4): 310-313.

链接本文:

https://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 https://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2025/V36/I4/310

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