富马酸伏诺拉生治疗Hp阳性消化性溃疡的临床效果

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Abstract Objective To investigate the clinical effect of fumarate in the treatment of Helicobacter pylori (Hp) positive peptic ulcer (PU). Methods A total of 94 HP-positive PU patients from the gastroenterology outpatient department of the Second Affiliated Hospital of Air Force Military Medical University from May 2022 to April 2024 were selected and randomly divided into control group and study group with 47 cases in each group. The control group was treated with amoxicillin + bismuth colloid pectin + clarithromycin + omeprazole, while the study group was treated with amoxicillin + bismuth colloid pectin + clarithromycin + fumarate Vonorazine orally for 2 weeks. The ulcer healing, Hp eradication, clinical efficacy, gastric acid secretion function and safety of the two groups were compared. Results The ulcer healing rate of the study group was 93.62% (44/47) higher than that of the control group (78.72% (37/47), and the difference was statistically significant (P<0.05). Compared with the control group, the eradication rate of Hp in the study group was higher (87.23% vs. 68.09%, P<0.05). The total effective rate of the two groups was higher in the study group (82.29% vs. 95.74%, χ²=7.029, P<0.05). After treatment, basal gastric acid secretion (BAO), maximum gastric acid secretion (MAO) and peak gastric acid secretion (PAO) decreased in both groups. The BAO, MAO and PAO levels in the study group were (4.15±1.44) mmol/h, (8.02±2.13) mmol/h and (12.12±3.67) mmol/h lower than those in the control group (5.36±1.98) mmol/h, (10.15±2.99) mmol/h and (15.01±3.59) mmol/h (t=3.388, 3.978, 3.859, P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (4.26% vs. 10.64%, P>0.05). Conclusions The treatment effect of fumarate on Hp positive PU is excellent, which is worthy of promotion due to the promotion of ulcer healing, inhibition of gastric acid secretion and its safety.

Key words： peptic ulcer helicobacter pylori Vonorazine fumarate gastric acid secretion function

Received: 09 July 2024

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	LIU Xiaogang
	ZHANG Jiaojiao
	YANG Ting
	LIU Chengwen

Cite this article:

LIU Xiaogang,ZHANG Jiaojiao,YANG Ting等. Clinical effect of fumarate on Hp positive peptic ulcer[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2025, 36(1): 30-33.

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https://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR https://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2025/V36/I1/30

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