缬沙坦与氨氯地平联合用药治疗原发性高血压的疗效

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Abstract Objective To investigate the clinical efficacy of valsartan / amlodipine combination and different time of taking medicine in treatment of essential hypertension. Methods 201 essential hypertensive subjects (92 men/109 women), were recruited randomized to receive valsartan(80 mg/day) and amlodipine (5 mg/day) in one of the following four therapeutic schemes: both medications on awakening, both at bedtime, either one administered on awakening and the other at bedtime. BP was measured by ambulatory monitoring for 24 consecutive hours before and after 12 wks of treatment. Results BP-lowering efficacy (quantified in terms of reduction of the 24-h mean of systolic/diastolic BP) was highest when both antihypertensive medicines were ingested at bedtime, as compared with any one of the three other tested therapeutic schemes[A(123.0±13.2)mmHg/(73.1±6.7)mmHg、B(113.6±11.0)mmHg/(67.1±8.3)mmHg、C(124.4±13.7)mmHg/(73.6±9.0)mmHg、D(119.8±13.0)mmHg/(70.6±7.2)mmHg,P<0.01]. Conclusions The greater proportion of controlled patients, improved efficacy on lowering asleep BP mean, and increased sleep-time relative BP decline suggest that valsartan/amlodipine combination therapy should be preferably administered at bedtime.

Key words： valsartan amlodipine essential hypertension combination therapy

Received: 09 March 2014

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	Articles by authors
	ZHOU Bin-Wei
	YUAN Yi
	BI Ying
	WANG Fei
	DUAN Jia-Jia
	LIU Xin-Lin
	ZHAO Ji-Hong

Cite this article:

ZHOU Bin-Wei,YUAN Yi,BI Ying等. Clinical effect of valsartan / amlodipine combination therapy in treatment of essential hypertension[J]. , 2014, 25(8): 774-776.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2014/V25/I8/774

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