奥氮平和丙戊酸钠治疗双相抑郁的疗效及安全性

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Abstract Objective To assess the efficacy and safety of olanzapine andsodium valproate monotherapy for bipolar depression. Methods Seventy-one patients who met DSM-IV criteria for bipolar depression were randomly assigned to treatment with olanzapine (n=35) or sodium valproate(n=36) in a double-blind parallel-group study design. The treatment duration was 8weeks.Planned assessments included Bech-Rafaelsen Mania Rating Scale(BRMs), Clinical Global Impressions-Improvement Scale (CGI-I), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Treatment Emergent Symptom Scale(TESS). Results Improvements in MADRS total score, CGI-I, and HAMD in the olanzapine group were not significantly different relative to those in the sodium valproate during the 8-week follow-up period (P<0.01, P=0.0017, P=0.007, and P<0.01, respectively).The rate of response(82.86％ and 55.88％,respectively)and remission(37.14％ and 26.47％,respectively)in olanzapine group and sodium valproate group,showed no statistically significant difference. But,olanzapine-treated group had a more rapid onset of effect than sodium valproate-treated patients in score of HAMA,with significant difference between two groups(P<0.01). Conclusions Olanzapine monotherapy is effective in the treatment of bipolar depression.

Key words： olanzapine bipolar depression sodium valproate

Received: 22 December 2014

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R749.053

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	WANG Jing
	SU Yaling

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WANG Jing,SU Yaling. Efficacy and safety of olanzapine and sodium valproate monotherapy in the treatment of bipolar depression:a flexible-dose randomised,double-blind study[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(5): 469-472.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I5/469

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