Duchenne型肌营养不良合并脊柱侧凸的危险因素分析

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Abstract Objective To study the risk factors for Duchenne muscular dystrophy associated with scoliosis,providing criteria for disease diagnosing. Methods 200 patients with diagnosis of Duchenne muscular dystrophy were recruited;79 of them having complication of scoliosis was assigned to the study group, and the rest to the control group.The related risk factorsfor Duchenne muscular dystrophy with scoliosis were analyzed using the single factor chi-square test and the multi-factor Logistic regression. Results Multiple-factor analysis results showed asymmetry of lower limb strength (OR=3.545,95CI:1.242-10.115), difficulty of working independently (OR=16.688,95CI:5.036-55.297), inconsistency of physical therapy (OR=0.068,95CI:0.015-0.305), contracture of achilles tendon that formed clubfoot (OR=1.597,95CI:0.462-5.524), and notreatment with hormone therapy (OR=1.464,95CI:1.437-5.439). Conclusions Asymmetry of lower limb strength, difficulty of working independently, inconsistency of physical therapy, contracture of achilles tendon that formed clubfoot, and notreatment with hormone therapy are the risk factors of Duchenne muscular dystrophy. Patients who have Duchenne muscular dystrophy associated with these risk factors should be monitored closely to prevent avoid the occurrence of scoliosis.

Key words： Duchenne muscular dystrophy scoliosis risk factors Logistic regression

Received: 04 December 2014

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	Articles by authors
	ZHU Ji
	KUANG Zhengda
	WU Shiwen
	ZHANG Xinyu

Cite this article:

ZHU Ji,KUANG Zhengda,WU Shiwen等. Analysis of risk facters for Duchenne muscular dystrophy associated with scoliosis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(5): 473-475.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I5/473

[1]	Kinali M, Main M, Eliahoo J, et al. Predictive factors for the development of scoliosis in Duchenne muscular dystrophy[J]. Eur J Paediatr Neurol,2007,11(3):160-166.
[2]	邱贵兴,庄乾宇. 青少年特发性脊柱侧弯的流行病学研究进展[J]. 中华医学杂志,2006,86(11):790-792.
[3]	李惠英. DMD肌肉病变机制研究[J].中国神经免疫学和神经病学杂志,2008,15(2):141-143.
[4]	张彬彬,刘晶瑶. DMD的研究进展[J].中风与神经疾病杂志,2011,28(2):187-189.
[5]	Lebel D E, Corston J A, McAdam L C, et al.Glucocorticoid treatment for the prevention of scoliosis in children with Duchenne muscular dystrophy: long-term follow-up [J].J Bone Joint Surg Am,2013,95(12):1057-1061.
[6]	麻宏伟.DMD症的诊断与治疗[J]. 中国实用儿科杂志,2007,22(7):552-554.
[7]	Alman B A, Raza S N, Biggar W D. Steroid treatment and the development of scoliosis in males with duchenne muscular dystrophy[J]. J Bone Joint Surg Am,2004,86(3):519-524.
[8]	Oda T, Shimizu N, Yonenobu K,et al.Longitudinal study of spinal deformity in Duchenne muscular dystrophy[J].J Pediatr Orthop,1993,13(4):478-488.
[9]	Yamashita T,Kanaya K,Kawaguchi S,et al.Prediction of progression of spinal deformity in Duchenne muscular dystrophy:a preliminary report[J].Spine,2001,26(11):223-226.
[10]	徐军.假肥大型进行性肌营养不良症患儿髓、膝运动功能分析[J]. 中国康复医学杂志,1994,9(4):149-152.