Ⅰb和Ⅱ期宫颈癌术后调强放疗的疗效

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (555 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To analyze the efficacy and treatment related toxicities for patients with Ⅰb and Ⅱ stage cervical cancer treated by Intensity Modulated Radiation Therapy (IMRT).Methods From January 2008 to February 2012,83 patients with stageⅠb-Ⅱ postoperative cervical cancer were retrospectively analyzed.The clinical target volume received a dose of 50 Gy/25 fractions in all patients.All patients were treated by IMRT and cisplatin-based chemotherapy for 2-4 cycles.Results Treatment was completed successfully in all patients. The follow-up rate was 100%. In all patients, the 3-year overall survival (OS) rate was 89.2％, with disease-free survival (DFS) rate of 83.1％ and pelevic local control (LC) rate of 85.5％. The 3-year OS rates were 50％ and 91％ for patients with adenocarcinoma and squamous carcinoma(χ²=9.65,P=0.002). The incidences of grade 1-2 rectal toxicity , urinary toxicity and myelosuppression were 10.34％,10.34％ and 58.62％. There were no grade 4 toxicities.Conclusions The postoperative cervical cancer patients with poor prognostic factors who undergo IMRT can achieve high overall survival rates,local control rates and tolerable toxicities.

Key words： cervical neoplasms/radiochemotherapy intensity modulated radiation therapy prognosis

Received: 19 March 2015

ZTFLH:

R737.33

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YANG Jian
	XU Xinming
	LIU Ying
	and XU Gang

Cite this article:

YANG Jian,XU Xinming,LIU Ying等. Efficacy of Ⅰb and Ⅱ stage cervical cancer treated by intensity-modulated radiotherapy after surgery[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(10): 1001-1003.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I10/1001

[1]	Torre L A, Bray F, Siegel R L, et al. Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015,62(2):87-108.
[1]	Torre L A, Bray F, Siegel R L, et al. Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015,62(2):87-108.
[2]	吴云燕, 梁美蓉, 李隆玉, 等. 1990-2007年4223例子宫颈癌住院患者的调查分析[J]. 中华妇产科杂志, 2008,43(6):433-436.
[2]	吴云燕, 梁美蓉, 李隆玉, 等. 1990-2007年4223例子宫颈癌住院患者的调查分析[J]. 中华妇产科杂志, 2008,43(6):433-436.
[3]	孙帅, 张福泉, 胡克, 等. 宫颈癌术后调强放疗同期化疗临床分析[J].中华放射肿瘤学杂志, 2013,22(1):13-16.
[3]	孙帅, 张福泉, 胡克, 等. 宫颈癌术后调强放疗同期化疗临床分析[J].中华放射肿瘤学杂志, 2013,22(1):13-16.
[4]	Cox J D, Stetz J, Pajak T F, et al. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) [J]. Int J Radiat Oncol Biol Phys, 1995,31(5):1341-1346.
[4]	Cox J D, Stetz J, Pajak T F, et al. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) [J]. Int J Radiat Oncol Biol Phys, 1995,31(5):1341-1346.
[5]	何超蔓, 梁峰冰, 陈曼玲, 等. 术前新辅助化疗治疗宫颈癌62例的疗效观察[J]. 中华医学杂志, 2012,92(5):327-329.
[5]	何超蔓, 梁峰冰, 陈曼玲, 等. 术前新辅助化疗治疗宫颈癌62例的疗效观察[J]. 中华医学杂志, 2012,92(5):327-329.
[6]	Rydzewska L, Tierney J, Vale C L, et al. Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer[J]. Cochrane Database Syst Rev, 2012,12:CD007406.
[6]	Rydzewska L, Tierney J, Vale C L, et al. Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer[J]. Cochrane Database Syst Rev, 2012,12:CD007406.
[7]	Biewenga P, van der Velden J, Mol B W, et al. Prognostic model for survival in patients with early stage cervical cancer[J]. Cancer, 2011,117(4):768-776.
[7]	Biewenga P, van der Velden J, Mol B W, et al. Prognostic model for survival in patients with early stage cervical cancer[J]. Cancer, 2011,117(4):768-776.
[8]	Pieterse Q D, Trimbos J B, Dijkman A, et al. Postoperative radiation therapy improves prognosis in patients with adverse risk factors in localized, early-stage cervical cancer: a retrospective comparative study[J]. Int J Gynecol Cancer, 2006,16(3):1112-1118.
[8]	Pieterse Q D, Trimbos J B, Dijkman A, et al. Postoperative radiation therapy improves prognosis in patients with adverse risk factors in localized, early-stage cervical cancer: a retrospective comparative study[J]. Int J Gynecol Cancer, 2006,16(3):1112-1118.
[9]	陈涛利, 卞翠翠, 杨雷, 等. 早期高危宫颈癌患者术后不同治疗方案的临床疗效[J]. 中国老年学杂志, 2015,(1):55-57.
[9]	陈涛利, 卞翠翠, 杨雷, 等. 早期高危宫颈癌患者术后不同治疗方案的临床疗效[J]. 中国老年学杂志, 2015,(1):55-57.
[10]	Van de Bunt L, Van der Heide UA, Ketelaars M, et al. Conventional, conformal, and intensity-modulated radiation therapy treatment planning of external beam radiotherapy for cervical cancer: The impact of tumor regression[J]. Int J Radiat Oncol Biol Phys, 2006,64(1):189-196
[10]	Van de Bunt L, Van der Heide UA, Ketelaars M, et al. Conventional, conformal, and intensity-modulated radiation therapy treatment planning of external beam radiotherapy for cervical cancer: The impact of tumor regression[J]. Int J Radiat Oncol Biol Phys, 2006,64(1):189-196
[11]	张瑾, 吴玉梅, 孔为民, 等. 763例Ⅲ期宫颈癌不同放疗方法的疗效分析[J]. 中华放射肿瘤学杂志, 2008,17(5):364-367.
[11]	张瑾, 吴玉梅, 孔为民, 等. 763例Ⅲ期宫颈癌不同放疗方法的疗效分析[J]. 中华放射肿瘤学杂志, 2008,17(5):364-367.