急性脑梗死合并脑白质疏松的危险因素分析

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Abstract Objective To study the risk factors of acute cerebral infarction in patients with leukoaraiosis (LA) and without leukoaraiosis (LA), and to explore the possible risk factors of LA.Methods Two hundred and seven patients of acute cerebral infarction, with or without LA, were divided into LA group (n=93) and non-LA group (n= 114).Clinical data was collected on age, hypertension, cerebral infarction, HCY, hsCRP, sex, smoking history, drinking history, diabetes, hyperlipidemia, and coronary heart disease of these patients. Logistic single-factor and multi-factor regression analysis was used to identify the risk factors.Results (1) Single-factor analysis suggested that there was statistically significant difference between LA group and non-LA group in age, hypertension, cerebral infarction, HCY and hsCRP (P<0.05), but not in gender, smoking history, drinking history, diabetes, hyperlipidemia or coronary heart disease. (2) Multivariate logistic regression analysis indicated that age, hypertension, history of cerebral infarction, HCY and hsCRP were risk factors of LA (P<0.05).Conclusions Age, hypertension, cerebral infarction, HCY and hsCRP are possibly associated with leukoaraiosis.

Key words： leukoaraiosis acute cerebral infarction risk factor

Received: 21 January 2017

ZTFLH:

R364.17

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	Articles by authors
	LI Jian
	ZHANG Jie
	XING Yan
	and WANG Yongjun

Cite this article:

LI Jian,ZHANG Jie,XING Yan等. Risk factors of patients with acute cerebral infarction complicated with leukoaraiosis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(5): 447-449.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I5/447

[1]	Hachinski V C, Potter P, Merskey H.Leukoaraiosis[J].Archives of Neurology,1987,44(1):21-23.
[2]	Verny M,Duyckaerts C,Pierot L,et al.Leukoaraiosis[J].Developmental Neuroscience,1991,13(13):245-250.
[3]	Fazekas F, Chawluk J B, Alavi A, Hurtig H I,et al.MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging[J].American Journal of Roentgenology, 1987,149(2):351-356.
[4]	Schmidt R, Fazekas F, Offenbacher H, et al.Neuropsychologic correlates of MRI white matter hyperintensities: a study of 150 normal volunteers[J].Neurology,1993,43(12):2490-2494.
[5]	于学英, 王桂红, 管小亭.门诊非痴呆患者单纯脑白质疏松的年龄特征[J].中华内科杂志, 2010, 49(6):488-490.
[6]	Inzitari D,Diaz F,Fox A,et al.Vascular risk factors and Leukoaraiosis[J].Archives of Neurology,1987,44(1):42-47.
[7]	Verhaaren B F, Vermooij M W,de Boer R,et al.High Blood Pressure and Cerebral White Matter Lesion Progression in the General Population[J].Hypertension,2013,61(6):1354-1359.
[8]	John A,Vincent P, Jean-Claude B,et al.Leukoaraiosis and ambulatory blood pressure load in a healthy elderly cohort study: The PROOF study[J].International Journal of Cardiology,2014,172(1):59-63.
[9]	Pierleone L, Roberto M, Roberto S,et al. Is there an association between leukoaraiosis volume and diabetes[J].Journal of Neuroradiology,2015,43(4):273-279.
[10]	Henninger N, Lin E, Baker S P, et al.Leukoaraiosis Predicts Poor 90-Day Outcome after Acute Large Cerebral Artery Occlusion[J].Cerebrovascular Diseases,2012,33(6):525-531.
[11]	Van den Heuvel DM, Admiraal-Behloul F, ten Dam VH, et al. Different progression rates for deep white matter hyperintensities in elderly men and women[J].Neurology,2004,63(9):1699-1701.
[12]	Streifler J Y, Eliasziw M, Benavente O R,et al.Development and Progrssion of Leukoaraiosis in Patients With Brain Ischemia and Carotid Artery Disease[J].Stroke,2003,34(8):1913-1916.
[13]	Naftali R, Yiqing Y, Cheryl L D, et al.Volume of white matter hyperintensities in healthy adults: Contribution of age,vascular risk factors,and inflammation-related genetic variants[J].Biochimica Et Biophysica Acta,2012,1822(3):361-369.
[14]	Kloppenborg R P, Nederkoorn P J, van der Graffle Y,et al. Homocysteine and cerebral small vessel disease in patients with symptomatic atherosclerotic disease. The SMART-MR study[J].Atherosclerosis,2011,216(2):461-466.
[15]	Corrado E,Rizzo M,Tantillo R,et al.Markers of inflammation and infection influence the outcome of patients with baseline asymptomatic carotid lesions: a 5-year follow-up study[J].2006,37(2):482-486.