参茸益精片对高原脑水肿血清IL-1β、TNF-α、MMP-9 水平的影响

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (373 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the influence of Ginseng essence-nourishing tablets on the levels of IL-1β、TNF-α andMMP-9 in high altitude cerebral edema patients.Methods Sixty-one patients with high altitude cerebral edema were treated with hyperbaric oxygen, intracraninal pressure, water and electrolyte balance maintenance, and oxygen inhalation.They were randomly divided into the observation group (31 cases) that was given Ginseng essence nourishing tablets and the control group (30 cases) that was not given such tablets. Their levels of IL-1β、MMP-9 and TNF-α of were measured by ELISA and immunofluorescence in both groups after fourteen days of treatment. Meanwhile, MMSE and ADL of these patients were evaluated.Results There was no statistically significant difference between the control group and observation group(P>0.05) in the concentration of IL-1β、TNF-γ and MMP-9 before treatment (P<0.05,P<0.01),but after fourteen days of treatment, the levels of these factors were significantly reduced, especially in the observation group (P<0.01).Conclusions By reducing the concentration of IL-1β、TNF-α and MMP-9, Ginseng essence nourishing tablets can alleviate the brain damage of hypoxic ischemia and improve clinical effects.

Key words： high altitude cerebral edema Ginseng nourishing essence tablets IL-1β MMP-9 TNF-α

Received: 20 February 2017

ZTFLH:

R742

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Haiwei
	ZHAO Cuimei
	HUO Jian
	WANG Ziqin
	and LV Hongdi

Cite this article:

WANG Haiwei,ZHAO Cuimei,HUO Jian等. Influence of Ginseng essence nourishing tablets for IL-1β、TNF-α、MMP-9 in patients with high altitude cerebral edema[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(6): 549-550.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I6/549

[1]	李小亮,刘文进,田书娟,等.脑出血大鼠血清炎性因子水平与脑水肿的相关性探讨[J].临床合理用药,2016,9(3A):108-122.
[2]	黄豫军,程晓玲,张振建,等.依达拉奉对急性脑出血患者血清MMP-9、TNF-α水平的影响[J].湖北医药学院学报,2015,34(6):589-591.
[3]	郝贵生,吴世政. 脑苷肌肽联合高压氧治疗高原脑水肿的疗效及对NSE影响的观察[J]. 高原医学杂志,2015,25(2):14-16.
[4]	武柠子,马慧萍,王宁,等. 脑水肿分子机制的研究进展[J]. 解放军医药杂志,2016,28(6):14-18.
[5]	Jiahong Zhu,Xinyi Mu,Jin Zeng,et al.Ginsenoside Rg1 Prevents Cognitive Impairment and Hippocampus Senescence in a Rat Model of D-Galactose-In-duced Aging[J].Plos One,2014,9(6):1-12.
[6]	李亮,邓文祥,何军锋,等.人参皂苷Rg1对局灶性脑缺血再灌注大鼠的神经保护作用[J].神经损伤与功能重建,2016,11(2):95-98.
[7]	曲友直,段君民,曹鹏,等.黄芪甲苷对脑缺血再灌注后脑组织MPO活性及TNF-α、IL-1β含量的影响[J].中西医结合心脑血管病杂志,2015,13(14):1620-1621.