宫血宁胶囊引起大鼠子宫平滑肌收缩及其初步影响机制研究

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Abstract Objective To investigate the mechanism underlying myometrial contraction stimulated by Gongxuening, and to provide reference for rational use of Gongxuening in the treatment of abnormal uterine bleeding.Methods The contraction of the uterus in vitro induced by Gongxuening in rats was observed using isolated uterine tension measurement, and the influence of such potential factors as epinephrine and its receptor modulators on the contraction was studied.Results It was found that epinephrine at the dose of 0.001μg/ml completely inhibited rat myometrial contractions induced by 50 μg/ml Gongxuening, while β₁ adrenergic receptor (β₁-AR) antagonists atenolol and metoprolol both completely reversed the inhibition by epinephrine. α-AR antagonist phentolamine could not reverse the inhibition by epinephrine during rat myometrial contractions induced by Gongxuening, although it completely inhibited myometrial contractions induced by α-AR agonist methoamine.Conclusions The possible mechanism of rat myometrial contractions induced by Gongxuening may be through inhibition of epinephrine β- AR activation.

Key words： Gongxuening myometrial contractions epinephrine adrenergic receptor

Received: 13 February 2017

ZTFLH:

R711.52

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	Articles by authors
	FU Tao
	WANG Limei
	ZHAO Zhenhu
	SHAN Yajun
	LIU Xiaolan
	and CONG Yuwen

Cite this article:

FU Tao,WANG Limei,ZHAO Zhenhu等. Inhibitory effect of Gongxuening on myometrial contractions and mechanisms[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(6): 557-559.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I6/557

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