无肝硬化乙肝患者肝癌发病影响因素分析

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Abstract Objective To investigate the risk factors of hepatitis B virus related hepatocellular carcinoma patients without cirrhosis.Methods A total of one thousand hepatocellular carcinoma patients were collected between January 2004 and December 2015-at Shanghai Corps Hospital of Chinese People’s Armed Police Force. The patients were divided into cirrhosis(n=934) group and non-cirrhosis(n=66) group according to whether there was cirrhosis of the liver. The general information and indexes of laboratory examination in both groups were analyzed retrospectively. χ² test and Logistic regression analysis were performed on the risk factors of hepatitis B virus related hepatocellular carcinoma patients without cirrhosis.Results The univariate analysis indicated that the difference in age, drinking of alcohol, overlap of hepatitis C virus infection, combination with hypertension, baseline serum e antigen status and serum HBV DNA levels, previous antiviral therapy and the family history of liver cancer were statistically significant between the two groups(P<0.05). The multivariate non-conditioned Logistic regression analysis of these eight factors indicated that drinking of alcohol(OR=0.176,P=0.002), combination with hypertension(OR=0.505,P=0.039), lower baseline serum HBV DNA levels (OR=0.031,P＜0.001), previous antiviral therapy (OR=7.268,P＜0.001) and the family history of liver cancer(OR=0.487,P=0.010) were independent risk factors which induce chronic hepatitis B to directly develop into hepatocellular carcinoma without cirrhosis.Conclusions Drinking of alcohol, combination with hypertension, low baseline serum HBV DNA levels, no previous antiviral therapy and the family history of liver cancer patients are possibly associated with the occurrence of hepatocellular carcinoma.

Key words： hepatitis B hepatocellular carcinoma cirrhosis influence factor

Received: 14 November 2016

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R735.7

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	Articles by authors
	WEI Yan
	YANG Yang
	WANG Zhe
	CHEN Jian
	JIANG Xuehua
	CHEN Yong
	and YANG Long

Cite this article:

WEI Yan,YANG Yang,WANG Zhe等. Influencing factors of hepatitis B virus related hepatocellular carcinoma patients without cirrhosis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(6): 564-566.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I6/564

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