肺保护性通气对膝关节置换术中氧合功能及肺顺应性影响

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Abstract Objective To investigate the effect of protective mechanical ventilation on lung compliance and oxygenation in patients undergoing total knee replacement surgery.Methods Forty patients undergoing total knee replacement surgery were randomly divided into two groups: protective mechanical ventilation group (Group V) and conventional ventilation group (Group C). All the patients were subjected to intermittent positive ventilation at an oxygen concentration of 70%, oxygen flow rate of 2 L/min and inhalation and exhalation ratio of 1:2. After induction, patients in Group V received protective mechanical ventilation, while those in Group C were under conventional ventilation. Pplat was monitored at the following time points: 5 min after general anesthesia (T₀), the start of surgery(T₁), 5min after bone cement inplantation (T₂), the end of surgery (T₃), and 15 min after extubation (T₄). Moreover, arterial blood samples were collected for the oxygenation index (OI) and compliance of the lung (CL) at these five time points.Results Compared with T₀, Pplat at T₂ and T₃ increased (P<0.05), but OI decreased at T₂ to T₄ (P<0.05) in Group C. In Group V, OI decreased at T₄ only (P<0.05). Patients in Group V showed a lower Pplat at T₂ and T₃, and a higher OI and CL between T₂ and T₄ than in Group C (P<0.05).Conclusions Protective mechanical ventilation may contribute to lung compliance and oxygenation, thus protecting lung function of patients undergoing total knee replacement surgery.

Key words： protective mechanical ventilation total knee replacement surgery oxygenation function lung compliance

Received: 07 March 2017

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	Articles by authors
	LI Juan
	ZHANG Wei
	CHEN Yu
	TIAN Ye
	and LV Hao

Cite this article:

LI Juan,ZHANG Wei,CHEN Yu等. Effect of protective mechanical ventilation on lung compliance and oxygenation in patients undergoing total knee replacement surgery[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(7): 668-671.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I7/668

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