两种麻醉药对急性颅脑外伤患者术后血清NSE、S100B蛋白、炎性因子及认知功能的影响

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Abstract Objective To explore the effect of propofol on serum NSE, S100B protein, inflammatory factors and cognitive function of patients with acute craniocerebral injury.Methods Ninety-eight patients who had been diagnosed with acute craniocerebral trauma and met criteria between January 2014 and December 2015 were selected. Using a random number table, they were equally divided into two groups and treated with fentanyl, vecuronium and etomidate for induction of anesthesia. The observation group received intravenous injection of propofol to maintain anesthesia while the control group received inhalation of isoflurane. Then, serum S100B protein and neuron specific enolase (NSE) content determined before operation, two hours into the operation, at the end of the operation and postoperative 48 h, and serum tumor necrosis factor TNF-α, interleukin IL-6 levels of preoperative and postoperative 48h were compared between the two groups. After 3 months and 6 months, the mini mental state examination scale (MMSE) was adopted to compare the neurological function recovery in the two groups after operation.Results The levels of serum S100B protein and NSE were not significantly different between the two groups before treatment. The serum S100B protein and NSE levels of the control group were higher than those of the observation group two hours into the operation, towards the end of surgery, and 48 hours after operation. There was no significant difference in serum IL-6 or TNF-α levels between the two groups before treatment but they were lower in the observation group than in the control group 48 hours after operation (P<0.05). The MMSE score of the two groups was not significantly different three months after operation, but was higher in the observation group than in the control group six months after operation (P<0.05).Conclusions Compared with isoflurane inhalation anesthesia, propofol intravenous anesthesia can effectively decrease the serum levels of inflammatory cytokines, reduce the degree of craniocerebral injury, and improve the cognitive function of patients with acute craniocerebral injury.

Key words： propofol isoflurane acute craniocerebral trauma cerebral protection

Received: 01 March 2017

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	Articles by authors
	LIU Chuanhui
	CHEN Hao
	QIU Qingming
	and DAI Ji

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LIU Chuanhui,CHEN Hao,QIU Qingming等. Effect of propofol on serum NSE, S100B protein, inflammatory factors and cognitive function of patients with acute craniocerebral injury[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(9): 905-908.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I9/905

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