炎性因子对多发伤患者预后评估的作用

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (503 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the prognostic value of wound inflammation factors in patients with multiple trauma.Methods One hundred and fourteen patients diagnosed with multiple traumas between February 2009 and March 2014 were enrolled in this study. Serum PCT, IL-6 and TNF-α levels were analyzed 1, 2, 4, 6, and 12 days after injury. According to the ISS score, patients with an ISS<16 points were included in the minor injury group (n=49) while those with an ISS ≥16 points were included in the severe injury group (n=65). The changes of inflammatory response factors were compared between the two groups.Results The serum PCT, IL-6 and TNF-α levels reached their peaks at the first day, second day and fourth day after injury respectively. The serum PCT, IL-6 and TNF alpha levels were lower in minor trauma group than in serious trauma group (P<0.05).Conclusions The changes in serum PCT, IL-6, TNF-α levels after injury could serve as ideal markers for prognosis prediction and are of high clinical value.

Key words： multiple traumas inflammation factors prognosis

Received: 11 June 2017

ZTFLH:

R641

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YI Lamu
	QI Yandong
	WAI Li
	GAO Hong
	YU Li
	ZHU Liang

Cite this article:

YI Lamu,QI Yandong,WAI Li等. Prognostic value of wound inflammation factors in patients with multiple traumas[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(12): 1246-1248.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I12/1246

[1]	包福祥,戴守勇,顾东明,等.控制性液体复苏治疗严重多发伤的疗效及其对血清炎性反应因子水平的影响[J].现代生物医学进展,2014,14(5):930-932.
[2]	涂悦,刁云锋,杨细平,等.乌司他丁对颅脑创伤合并多发伤患者的治疗作用[J].中国危重病急救医学,2012,24(11):677-679.
[3]	孔令文,卢仁富,谭云康,等.应用ISS和NISS评估伴严重胸部的多发伤患者并发症与救治结局[J].中华创伤杂志,2012,28(7):580-583.
[4]	刁云锋,杨细平,涂悦,等.血必净注射液对重型颅脑创伤后肺部感染患者血清炎性反应介质表达的影响[J].中国中西医结合急救杂志,2012,19(4):200-202.
[5]	刘震宇,苏文利,王毅鑫,等.山莨菪碱联合乌司他丁对危重型多发伤患者血清炎性反应因子的影响[J].中国急救医学,2013,33(1):23-25.
[6]	黄国兵,潘学武,曹盛生,等.颅脑损伤合并多发伤的预后影响因素分析及急诊救治探讨[J].中华神经医学杂志,2013,12(8):819-822.
[7]	彭媛,陆士奇,刘龙,等.活化蛋白C炎性反应因子在严重多发伤患者早期凝血障碍中的临床研究[J].中国急救医学,2013,33(11):1002-1005.
[8]	陈宁波,曾杰,李艳,等.应用乌司他丁治疗严重多发伤血清IL-6、IL-8、IL-10、TNF-α的表达及临床意义[J].四川医学,2013,34(1):1-4.
[9]	刘明华,田君,陈翔宇,等.多发伤患者早期促血管生成素-2的变化及临床意义[J].中华创伤杂志,2010,26(4):328-331.
[10]	彭建,李万逸,李海平,等.活血清热法对骨科多发伤患者血清TNF-α、IL-1、IL-6因子水平的调控[J].光明中医,2013,28(8):1592-1594.
[11]	周强.多发创伤患者血清α-MSH含量的变化及与炎性反应的关系[D].太原:山西医科大学,2011.
[12]	殷晓娟,李大鹏,尹其翔,等.血清PCT、IL-6水平及SIRS对严重多发伤脓毒血症早期诊断临床研究[J].临床急诊杂志,2011,12(3):186-188.
[13]	曾杰,陈宁波,张健,等.IL-6、IL-8、IL-10、TNF-α在严重多发伤的表达及与预后的相关性研究[J].四川医学,2013,34(3):289-292.
[14]	唐云芳.多发伤患者致炎因子与抗炎因子的变化及预后价值[J].放射免疫学杂志,2011,24(2):237-239.
[15]	马玉东,孟凡鑫,宋岩,等.血清IL-6、CRP和PCT水平对严重多发伤后MODS的预测价值[J].解剖科学进展,2013,19(1):32-34.