慢性心力衰竭患者血清25-(OH)D<sub>3</sub>、hsCRP及NT-proBNP水平与心力衰竭程度和预后的相关性

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Abstract Objective To analyze and explore the expressions of serum 25(OH)D₃, hsCRP and NT-proBNP in patients with different degrees of heart failure, and to study their correlations with and guidance for the prognosis of the disease.Methods One hundred and eight patients with chronic heart failure who had been diagnosed at our hospital between 2015 and 2017 were selected as the study group, while another 108 healthy subjects were randomly selected as the control group. Serum 25(OH)D₃, hsCRP and NT-proBNP values were compared between the two groups.The degree of heart failure and changes in three serum factor values in case of major adverse cardiovascular events (MACE, including cardiovascular death, nonfatal myocardial infarction and stroke) were observed.Results Compared with control group, the serum 25(OH)D₃ detection value decreased significantly, while the detection value of hsCRP and NT-proBNP increased significantly, and the difference was statistically significant (P<0.05). In the study group, 25(OH)D₃ was (20.85±4.87) ug/L, hsCRP (10.58±3.04)mg/L and NT-proBNP (926.17±267.11) pg/ml after treatment, compared to (14.56±4.33) μg/L, (17.69±3.68 )mg/L and (1588.64±574.39) pg/ml, so the difference was statistically significant (P<0.05). As the severity of heart failure increased, the detection value of serum 25(OH)D₃ decreased significantly, while those of serum hsCRP and NT-proBNPwere significantly increased, with statistical significance (P<0.05). Serum 25(OH)D₃ of patients with MACE was(10.62±3.44) μg/L, lower than (14.29±3.21) μg/L among those without MACE, but serum hsCRP of the former was(18.99±3.25 mg/L0, and NT-proBNP was(1688.34±375.66) pg/ml, compared to(15.76 ± 1.34) mg/L and (1320.48±262.77) pg/ml of the latter, and the difference was of statistical significance (P<0.05).Conclusions During the progression of chronic heart failure, the expression levels of serum 25(OH)D₃, hsCRP and NT-proBNP can help the diagnosis of the severity of heart failure. The three indicators can improve with more effective control of the disease.

Key words： 25-(OH)D₃ relationship hsCRP degree of heart failure and prognosis NT-proBNP

Received: 12 December 2017

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	WANG Anhui

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WANG Anhui. Correlations of serum 25- (OH)D₃, hsCRP and NT-proBNP levels with degree of heart failure and prognosis in patients with chronic heart failure[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(4): 367-370.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I4/367

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