二甲双胍联合利拉鲁肽对多囊卵巢大鼠炎性因子及性激素水平的影响

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Abstract Objective To study the effect of metformin combined with liraglutide on changes of inflammatory factors and hormonal readiness in polycystic ovary syndrome (PCOS) rats induced by dehydroepiandrosterone.Methods Eighty rats with PCOS that was induced by dehydroepiandrosterone were randomly divided into control group (n=40)and intervention group (n=40). The control group was given by ig melbine (270 mg/kg·d), and the intervention group was given by ig melbine (270 mg/kg·d) + lumbar injection liraglutide (5 μg/kg·d). The treatment lasted 28 days. Before and after treatment, the changes of interleukins-6(IL-6), tumour necrosis factor-α(TNF-α) , C-reactive protein (CRP), follicule-stimulating hormone (FSH), luteinizing hormone (LH), LH/FSH, estrogen (E₂), and testosterone (T) were observed.Results After treatment, IL-6 was(23.88±7.32) pg/ml, TNF-α(13.24±2.23) ng/L, CRP(1.10±0.19) mg/L,LH(6.57±1.37) mIU/ml, LH/FSH(1.17±0.28), E₂(1.11±0.18) pg/mL, and T(12.21±1.32) ng/dL, which were all lower than before treatment in both groups (P<0.05), while FSH(5.63±0.77) mIU/ml was higher than before treatment in both groups (P<0.05).Conclusions Metformin combined with liraglutide can reduce the concentration of inflammatory factors and hormonal readiness, which can facilitate clinical practice.

Key words： metformin liraglutide polycystic ovary syndrome inflammatory factor hormonal readiness

Received: 08 December 2017

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	Articles by authors
	ZENG Binyang
	SUN Yukun
	SHI Lili
	KANG Jingjia
	ZHAO Xing
	HUANG Haidong
	ZHANG Shanshan
	YANG Yueli

Cite this article:

ZENG Binyang,SUN Yukun,SHI Lili等. Effect of metformin combinated with liraglutide on changes of inflammatory factors and hormonal readiness in PCOS rats[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(4): 371-373.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I4/371

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