<sup>18</sup>F-FDG PET/CT对非小细胞肺癌EGFR基因突变诊断价值的Meta分析

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Abstract Objective To evaluate the diagnostic value of ¹⁸F-FDG PET/CT for EGFR gene mutation in non-small cell lung cancer with Meta analysis.Methods Databases that had been searched included PubMed, EMbase, the Cochrane Library, Chinese Journal Full-text Database, Wanfang Database, Chinese Science and Technology Database. Diagnostic tests related to EGFR gene mutation in non-small cell lung cancer and involving ¹⁸F-FDG PET/CT were investigated and analyzed. Meta-analysis was performed using Meta DiSc 1.4 software after two reviewers independently screened the literature for inclusion and exclusion criteria, extracted the data and evaluated the methodological quality of the included studies.Results 16 articles and 3308 cases of non-small cell lung cancer patients were included. Meta-analysis results showed that the incorporated SEN averaged 0.57[95% CI (0.55,0.60)], incorporated SPE 0.65[95% CI (0.62,0.67) CI (1.49,2.23)], incorporated LR 0.67[95% CI (0.59,0.76)], and incorporated DOR 2.93[95% CI (2.08,4.15)], while AUC was 0.6678.Conclusions SUVmax of ¹⁸F-FDG PET/CT is of predictive value for the mutation of EGFR in NSCLC patients with better specificity than sensitivity, which can be used to predict the mutation of EGFR in NSCLC patients.

Key words： non-small cell lung cancer PET/CT 18F-FDG EGFR

Received: 09 February 2018

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	Articles by authors
	YANG Yang
	HUANG Shiming
	GANG Bo
	CHEN Qinghua
	and LIN Zhichun

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YANG Yang,HUANG Shiming,GANG Bo等. Diagnostic value of ¹⁸F-FDG PET/CT for EGFR gene mutation in non-small cell lung cancer:a Meta analysis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(5): 448-452.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I5/448

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