急性冠脉综合征并糖尿病老年患者血清BNP与不良心血管事件的相关性

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Abstract Objective To investigate the correlations between serum BNP levels and the incidence of adverse cardiovascular events in patients with diabetes complicated with acute coronary syndrome.Methods Clinical data on 221 patients with acute coronary syndromes complicated with diabetes mellitus treated in our hospital was retrospectively analyzed, All these patients had their levels of BNP detected and received cardiac ultrasound and coronary angiography. The cardiac function of the patients was evaluated before they were divided into the ascending group (>100 pg/ml) and normal group (<100 pg/ml) according to BNP levels. The correlations between elevated BNP levels and cardiac function grading, ejection fraction and coronary artery lesion severity were investigated. Follow-up was conducted two months, six months and 12 months after the onset, involving such indexes as mortality and cardiovascular events before the difference in outcome indicators were compared between the two groups.Results (1) Among the 144 cases of patients with elevated BNP, there were 48 cases of cardiac function grade Ⅱ, the BNP concentration was (223.0±89.1)pg/ml, LVEF was (60.3±8.3)%, and the Gensin score of coronary artery lesions was(27.4±10.8) points. Among the 52 cases of cardiac function grade Ⅲ, the BNP concentration was(423±125.5 )pg/ml, LVEF was (46.5±7.4)%, and the Gensin score of coronary artery lesions was (56.5±18.4). Among the 44 cases of cardiac function grade Ⅳ, the BNP concentration was (665.0±157.5) pg/ml, LVEF was (35.0~4.5)%, and the Gensin score of coronary artery lesions was(83.1±29.7)points. The difference in LVEF and BNP levels and in coronary artery lesion severity was statistically significant between patients of different grades of cardiac function. The BNP level was negatively correlated with LVEF, which was positively correlated with the severity of coronary artery disease and cardiac function. (2) There was no statistically significant difference in the death toll or the number of patients with recurring myocardial infarction 2, 6 months and 12 months after the onset, but there was statistically significant difference in the number of inpatients due to recurring myocardial infarction. Kaplan-meier analysis showed that the survival rate of the ascending group was significantly higher than that in the normal group(P=0.019).Conclusions Serum BNP levels can be used as an indicator for the diagnosis and prediction of long-term adverse cardiovascular events in diabetic patients with acute coronary syndrome.

Key words： acute coronary syndrome diabetes b-type natriuretic peptide adverse cardiovascular events

Received: 10 December 2017

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	Articles by authors
	QU Miao
	MENG Kaishun
	HONG Luxian
	and HE Bining

Cite this article:

QU Miao,MENG Kaishun,HONG Luxian等. Correlations between serum BNP levels and adverse cardiovascular events in elderly patients with acute coronary syndrome and diabetes mellitus[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(7): 693-692.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I7/693

[1]	郑虹,米树华,赵全明,等.血浆B型脑钠肽与急性冠状动脉综合征患者冠状动脉病变Gensini积分关系的研究[J].中国医药,2015,10(1):46-50.
[2]	黄春,马武芝.血清脑钠尿肽与D二聚体检测在急性冠状动脉综合征的意义[J].血栓与止血学,2016,22(4):415-416.
[3]	中华医学会心血管病学分会,中华心血管病杂志编辑委员会.急性ST段抬高型心肌梗死诊断和治疗指南[J].中华心血管病杂志,2015,43(5):380-393.
[4]	杨薛萍,李倩.B型钠尿肽与心血管疾病关系的研究进展[J].中华全科医学,2013,11(3):458-459.
[5]	李继红,邹佳.肌钙蛋白Ⅰ、肌红蛋白、肌酸激酶同工酶在急性心肌梗死诊断中的应用[J].武警医学,2012,23(7):638-639.
[6]	葛剑力,邵莉,滕丽莉,等.可溶性ST2在急性冠脉综合征患者预后评估中的价值[J].中国老年学杂志,2014,(21):5970-5973.
[7]	朱小刚,韩凌,赵燕,等.BNP、LVEF和年龄对非ST段抬高性急性冠脉综合征患者院内恶性室性心律失常的预测价值[J].临床和实验医学杂志,2016,15(20):2007-2010.
[8]	廖育山,洪长江,李志雄,等.高剂量与低剂量瑞舒伐他汀对急性冠脉综合征患者血清脑钠肽、炎性因子及血脂水平的影响观察[J].临床与病理杂志,2016,36(9):1393-1398.
[9]	李凤,李来传,史有奎,等.C-反应蛋白、D-二聚体及肌钙蛋白在诊断急性心血管病中的应用[J].辽宁医学院学报,2013,34(6):23-25.
[10]	黄勇先,郭俊瑾,朱晓明,等.血清降钙素原和超敏C反应蛋白与非ST段抬高急性冠脉综合征危险分层的相关性研究[J].辽宁医学杂志,2016,30(6):32-35.
[11]	杨朝美,李逊,马珍,等.血清 BNP、hs-CRP、IMA 与冠状动脉粥样硬化性心脏病患者的相关性研究[J].中国实验诊断学,2015(7):1077-1079.
[12]	郭玉萍,徐茂椿,高修仁,等.冠心病者血浆脑钠素氨基末端前体浓度及超声左室射血分数的临床意义[J].中山大学学报(医学科学版),2007,28(1):129-131.
[13]	郑志君,孙毓川,王张锋,等.急性冠状动脉综合征患者氨基末端B型利钠肽前体与全球急性冠状动脉事件注册评分及心功能关系的临床研究[J].中国综合临床,2014,30(9):935-938.
[14]	程华锋,段欣,王威,等.急性冠脉综合征合并心源性休克术后伴发认知功能障碍的影响因素[J].武警医学,2017,28(7):690-697.
[15]	关海林.血清N端B型脑钠肽前体水平检测在治疗ACS中的临床意义[J].中国医学创新,2014(11):69-71.
[16]	黄玉娜,王玉丰.急性冠状动脉综合征患者介入治疗前后NT-pro BNP水平的变化[J].国际检验医学杂志,2013,34(8):1038-1039.