快速康复外科理念结合七氟醚、异丙酚全麻对老年乳腺癌术后苏醒时间及认知功能的影响

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Abstract Objective To compare the effects of sevoflurane and propofol general anesthesia on recovery time and postoperative cognitive function in elderly patients with breast cancer after FTS.Methods Sixty-two elderly patients with breast cancer treated in our hospital were randomly divided into the sevoflurane group and propofol group (n=31). The two groups were anesthetized with etomidate, fentanyl, vecuronium, and midazolam. Anesthesia was maintained with sevoflurane in the sevoflurane group, but with propofol in the propofol group. The anesthetic effect of the two groups was evaluated. The time the patients recovered spontaneous breathing, the time they opened their eyes, the time they resumed their sense of orientation and the Aldrete score were statistically analyzed.The incidence of cognitive impairment after operation was evaluated by a simple intelligent mental state score (MMSE score).Results The excellent and good rate of anesthetic effect was 100% in both groups. There was no significant difference between the two groups. The propofol group took less time to recover their spontaneous breathing, to resume their ability to open their eyes and tell the direction than the sevoflurane group (P<0.05), but the average Aldrete score of the sevoflurane group was lower than that of the propofol group (P<0.05) . 2 h after operation, the average MMSE score in the two groups became lower (P<0.05). The incidence of cognitive dysfunction was 38.71% in the sevoflurane group, compared with 19.35% in the propofol group. The rate of cognitive dysfunction was 22.58% in the postoperative 12 h in the sevoflurane group, but was 9.68% in the propofol group.Conclusions Both sevoflurane and propofol can be used for effective anesthesia in elderly patients with breast cancer, but propofol is more effective for the recovery of consciousness under the concept of FTS by reducing the incidence of cognitive impairment after operation and contributing to rehabilitation.

Key words： fast track surgery breast cancer old age anesthesia sevoflurane propofol

Received: 01 March 2018

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	DOU Tianyou
	HUO Yan
	LI Junhui

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DOU Tianyou,HUO Yan,LI Junhui. Effect of sevoflurane and propofol general anesthesia on recovery time and postoperative cognitive function in elderly patients with breast cancer after FTS[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(8): 766-769.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I8/766

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