理气活血滴丸对冠心病心绞痛的疗效及对患者情绪状态、血清CRP、TNF-α、IL-6水平的影响

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To analyze the effect of Liqi Huoxue (qi-regulating and blood-activating) drop pills on the improvement of clinical symptoms, emotional state, recurrence rate, long-term quality of life, serum CRP, TNF- alpha and IL-6 levels in patients with coronary heart disease (CHD).Methods Ninety-four patients with angina pectoris treated between April 2014 and August 2016 were randomly divided into the control group and the observation group, with 47 cases in each. The control group received conventional treatment, while the observation group was additionally treated with Liqi Huoxue drop pills. The course of treatment lasted for 4 weeks, and follow-up went on for more than 6 months.Improvement of clinical symptoms, recurrence rate, long-term quality of life, and serum CRP, TNF- alpha and IL-6 levels before and after treatment were compared between the two groups.Results After treatment, the total effective rate was 82.98% in the control group and the recurrence rate was 19.15% in the follow-up period, compared with 97.87% and 4.26% in the observation group. There was statistically significant difference between the two groups (P<0.05).There was no significant difference in HAMD scores or SF-36 scores between the two groups before treatment. Six months after treatment, the HAMD score of the observation group was lower than that of the control group, but the SF-36 score was higher than that of the control group, and there was statistically significant difference between the two groups (P<0.05). Serum CRP, TNF- alpha and IL-6 levels were not significantly different between the two groups of patients before treatment.However, after treatment, these levels were lower in the observation group than in the control group, and there was significant difference between the two groups (P<0.05). The rate of adverse reactions of the control group was 10.64% during the treatment, compared with 14.89% in the observation group, and there was no significant difference between the two groups.Conclusions Liqi Huoxue dropping pills, when used as an adjunctive therapy for coronary heart disease and angina pectoris, helps relieve the clinical symptoms of the patients, reduce the risk of recurrence, and improve the long-term quality of life of patients. Reducing the level of serum inflammatory factors may be one of the mechanisms by which these pills can help treat coronary heart disease and angina pectoris.

Key words： Liqi Huoxue dropping pills coronary heart disease angina pectoris clinical efficacy quality of life inflammatory factors

Received: 20 January 2018

ZTFLH:

R581.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Siming
	LIU Ming

Cite this article:

WANG Siming,LIU Ming. Effect of Liqi Huoxue drop pills on clinical symptoms, emotional state,recurrence rate, long-term quality of life, serum CRP, TNF- alpha and IL-6 levels in patients with coronary heart disease and angina pectoris[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(8): 770-773.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I8/770

[1]	宇丽艳, 丰小星, 顾岩,等. 冠心病患者PCI术后康复时机对患者心功能影响[J]. 现代仪器与医疗, 2017, 23(4):128-130.
[2]	马维军,王海燕.通心络联合氯吡格雷治疗对冠心病心绞痛临床症状及血流动力学的影响[J].中国老年学杂志,2015,8(5):1197-1199.
[3]	国际心脏病学会和协会及世界卫生组织临床命名标准化联合专题组.缺血性心脏病的命名及诊断标准[J].中华心血管病杂志,1981,9(1):75.
[4]	国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:18.
[5]	中西医结合治疗冠心病心绞痛及心律失常座谈会.冠心病心绞痛及心电图疗效评价标准[J].中国药事,1987,1(2):71.
[6]	Gul M,Uyarel H,Ergelen M,et al.Predictive value of neutrophil to lymphocyte ratio in clinical outcomes of non ST elevation myocardial infarction and unstable angina pectoris: a 3-year follow up[J].Clin App Thromb, 2014,20(4):378-384.
[7]	宋婷婷,王东海,刘呈宇,等.温阳活血方治疗阳虚血瘀型冠心病心绞痛的疗效观察[J].中西医结合心脑血管病杂志,2014,8(6):668-669.
[8]	李力,徐照,吴春叶,等.补气活血方治疗冠心病心绞痛的临床疗效及对炎性反应的干预作用[J].中医药信息,2017,34(3):89-92.
[9]	姚雪靖. 自拟活血通脉冠心汤治疗冠心病心绞痛临床疗效观察[J].河北医学,2014,3(9):1565-1567.
[10]	陈韦,丁伟.活血化痰法治疗冠心病心绞痛[J].长春中医药大学学报,2015,31(5): 973-975.
[11]	Medina C E,Pontigo A P,Perez E,et al.Association between edentulism and angina pectoris in mexican adults aged 35 years and older: a multivariate analysis of a population-based survey[J].JOP, 2014,85(3):406-416.
[12]	占甘伟,汪宏良,李艳,等.益气养阴活血汤联合西药对冠心病心绞痛血清C反应蛋白、肿瘤坏死因子-α、血脂水平、血液流变学水平的影响[J].国际检验医学杂志,2016,37(7): 935-937.
[13]	陈永华. 中西医结合治疗冠心病心绞痛临床研究[J].中医学报,2014,29(2):269-271.
[14]	郑珂,赵明.温阳活血法治疗70例冠心病心绞痛的临床观察[J].中医药信息,2015,7(2):92-94.
[15]	刘如秀,徐利亚,刘金凤,等.滋肾通阳活血方联合西药治疗冠心病心绞痛临床研究[J].中国中医药信息杂志,2014,4(8):23-26.