生脉地黄汤治疗糖尿病肾病的疗效及对血清胱抑素C水平的影响

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (739 KB) HTML (0 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the clinical efficacy of Shengmai Dihuang decoction in the treatment of early and middle stage diabetic nephropathy and its effect on serum cystatin C (Cys-C) and other indicators.Methods One hundred and two patients with early-stage diabetic nephropathy (DN) admitted to our hospital between January 2016 and January 2018 were selected as the subjects,who were divided into the control group and the observation group. The control group was given routine treatment while the observation group was additionally given self-designed Shengmai Dihuang decoction. One course of treatment lasted 3 months.The clinical efficacy of the two groups was evaluated after one course of treatment, and changes in renal function indicators, blood glucose indicators and serum marker expression levels of the two groups of patients were observed after treatment.Results The total effective rate of the observation group was 92.16%, compared with 72.55% in the control group, so the difference was statistically significant.The difference in such blood glucose indexes as FBG,2hPG and HbA₁c, in renal function indexes including SCr,BUN, U-β₂MG, and total urine protein at 24 h and in such serum markers as Cys-C,RBP,and Hcy was statistically significant between the two groups (P<0.05)after treatment. All the above indicators in the observation group were better than those in the control group(P<0.05).Conclusions Shengmai Dihuang decoction is effective in the treatment of diabetic nephropathy and can effectively improve the renal function of patients and reduce the expression levels of serum Cys-C markers.

Key words： diabetic nephropathy cystatin C homocysteine renal function Traditional Chinese Medicine

Received: 11 May 2018

ZTFLH:

R587.24

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIANG Hengfen
	TANG Zhengying
	WANG Sheng

Cite this article:

LIANG Hengfen,TANG Zhengying,WANG Sheng. Clinical effect of Shengmai Dihuang decoction against diabetic nephropathy and its effect on serum cystatin C levels[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(11): 1058-1061.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I11/1058

[1]	刘洁,滑丽美. 糖尿病肾病的营养状况及膳食治疗的相关性研究[J].武警医学, 2017,28 (10) :1057-1060.
[2]	王东,李阳欣,李敬林.从脾肾亏虚论治糖尿病肾病[J].辽宁中医杂志,2017,44(1):60-62.
[3]	郑晓东,冯燕,韩磊.芪蛭降糖胶囊对糖尿病肾病的疗效分析[J].中华中医药学刊,2018,36(4):994-996.
[4]	Mori J,Patel V B,Ramprasath T,et al. Angiotensin 17 mediatesrenoprotection against diabetic nephropathy by reducing oxidativestress,inflammation,and lipotoxicity[J].Am J Physiol RenalPhysiol,2014,306(8):812-821.
[5]	宋丽妮,刘敬怡,张怡尘.糖尿病肾病早期诊断标志物的研究新进展[J].首都医科大学学报,2017,38(2):145-150.
[6]	周全,李海霞,王丽,等.益气养阴活血汤对早期糖尿病肾病患者血清IL-17A、IL-18、TNF-α的影响[J].中药材,2018,41(2):486-488.
[7]	中华中医药学会肾病分会.糖尿病肾病诊断、辨证分型及疗效评定标准(试行方案)[J].上海中医药杂志,2007,41(7):7-8.
[8]	Mogensen C E.Management of early nephropathy in diabeticpatients[J].Annu Rev Med,1995,46:79-93.
[9]	郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:233-237.
[10]	Zhang M H,Feng L,Zhu M M,et al. The anti-inflammation effectof Moutan Cortex on advanced glycation end products-induced ratmesangial cells dysfunction and high-glucose-fat diet and streptozo-tocin-induced diabetic nephropathy rats[J].J Ethnopharmacol,2014,151(1):591-600.
[11]	张兆和,林祖辉,张征宇.健脾益肾降浊法治疗糖尿病肾病的临床疗效观察[J].中国全科医学,2014,17(6):703-705.
[12]	褚书豪,汪小彩,冯良.太子参化学成分及其药理作用研究进展[J].光明中医,2016,31(7):1047-1048.
[13]	李乃谦.熟地黄活性成分药理作用的研究进展[J].中国处方药,2017,15(1):14-15.
[14]	梁荣琰.山药的药理学研究及现代化应用[J].世界最新医学信息文摘,2015,15(a3):192-193.
[15]	黄赞鸿,张惜铃,陈义杰,等.联合检测Cys-c、Hcy和RBP在糖尿病肾病早期诊断中的意义[J].实用医学杂志,2017,33(2):292-295.