银杏叶提取物对氯吡格雷人体内药动学影响

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Abstract Objective To study the effects of Ginkgo biloba extract on pharmacokinetics of clopidogrel and its mechanism.Methods Fourteen healthy male volunteers took a single 100-mg oral dose of clopidogrel either alone or after pretreatment with 240 mg Ginkgo biloba extract daily for 14 days. On day 14, a single 100-mg oral dose of clopidogrel was administered. Plasma SR26334 concentrations of clopidogrel from zero to 24 h were measured by high-performance liquid chromatography.Results AUC_(0-t)(3192.3±45.035), AUC_(0-∞)(3343.017±43.829) and C_max(340.988±11.257) of SR26334 in the combination group was significantly higher than that of the single-drug group (P<0.05).Conclusions Ginkgo biloba extractcan increase the bioavailability and absorption of clopidogrel. The mechanism may be related to Ginkgo biloba’s significant inhibition of P-glycoprotein.

Key words： Ginkgo biloba clopidogrel SR-26334 pharmacokinetics

Received: 01 August 2018

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R364.17

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	Articles by authors
	WANG Dongyin
	HUANG Qiuling
	CHEN Lifeng
	and CHEN Zhimin

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WANG Dongyin,HUANG Qiuling,CHEN Lifeng等. Effect of Ginkgo biloba extract on pharmacokinetics of clopidogrel and its mechanism[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(12): 1133-1137.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I12/1133

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