自拟祛痰通腑化瘀方对脑梗死恢复期(痰热瘀结证)患者血液流变学及血清UCH-L1、NSE、VEGF水平的影响

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (740 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To study the effects of self-made Qutan Tongfu Huayu Prescription on hemorheology and serum levels of ubiquitin carboxyl terminal hydrophenol-1 (UCH-L1), neuron-specific enolase (NSE), and vascular endothelial growth factor (VEGF) in patients with cerebral infarction in the convalescent stage (phlegm-heat stagnation syndrome).Methods A total of 84 patients with cerebral infarction in the convalescent stage (phlegm-heat-stasis syndrome) admitted to our hospital between March 2017 and March 2018 were selected and randomly were divided into the observation group and control group. The control group was received routine treatment, while the observation group was additionally treated with self-made Qutan Tongfu Huayu Prescription. Changes related to the National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI), blood lipid, and hemorheology were observed before and after treatment. The levels of UCH-L1, NSE, and VEGF in serum were detected.Results After treatment, the NIHSS, BI score and blood lipid improvement of the observation group were better than those of the control group, and the difference was of statistical significance (P<0.05). After treatment, the plasma viscosity[(0.81±0.22)mpa·s], whole blood high shear viscosity[(4.31±0.54)mpa·s], whole blood low shear viscosity[(10.17±1.26)mpa·s], whole blood reduced viscosity [(11.16±1.52)mpa·s] and platelet aggregation index (53.73±5.81) in the observation group were significantly lower than those in the control group[(1.37±0.25),(6.43±1.29),(12.05±1.37),(15.38±1.78)mpa·s,(65.81±6.74)], and the difference was statistically significant (P<0.05). After treatment, the average cerebral blood flow perfusion velocity[(45.27±4.93)cm/s] and the peak systolic flow velocity[(73.45±7.92)cm/s]of the observation group were significantly higher than those of the control group[(37.49±3.95),(63.73±6.84)cm/s]. The resistance index was (0.61±0.07), which was significantly lower than that of the control group (0.74±0.08), so the difference was statistically significant (P<0.05). After treatment, the serum UCH-L1[(134.82±14.57)pg/ml] and NSE[(12.35±1.52)μg/L]in the observation group were significantly lower than those in the control group[(193.41±20.52)pg/ml,(16.51±1.93)μg/L]. The serum vascular endothelial growth factor level was[(381.57±41.82)pg/ml], which was significantly higher than that in the control group[(312.43±34.62)pg/ml], so the difference was statistically significant (P<0.05).Conclusions The self-made Qutan Tongfu Huayu Prescription can significantly improve blood lipid and hemorheology of patients with cerebral infarction in the convalescent stage, increase cerebral blood flow, promote the recovery of nerve function, and improve daily productivity, which is a feasible treatment.

Key words： Qutan Tongfu Huayu Prescription the convalescent stage of cerebral infarction phlegm-heat stagnation syndrome hemorheology

Received: 15 January 2019

ZTFLH:

R743.3

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	SHAN Yuheng
	LIN Yanchen
	ZHONG Shijiang

Cite this article:

SHAN Yuheng,LIN Yanchen,ZHONG Shijiang. Effects of Self-made Qutan Tongfu Huayu Prescription on hemorheology, serum UCH-L1, NSE, and VEGF levels in patients with cerebral infarction in convalescent stage[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(7): 580-583.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I7/580

[1]	陈思, 陆斌, 尹文伟,等. 参芪扶正注射液联合尼莫地平对脑梗死恢复期患者血液指标的影响[J]. 中国药房, 2016, 27(5): 683-685.
[2]	王安安, 李文娟. 脑梗死恢复期中西医治疗进展[J]. 中西医结合心脑血管病杂志,2016,14(24):2900-2902.
[3]	郑筱萸. 中药新药临床研究指导原则(试行)[M]. 北京:中国医药科技出版社, 2002: 99-104.
[4]	国家中医药管理局脑病急症科研组. 中风病辨证诊断标准(试行)[J]. 北京中医药大学学报, 1994, 17(3): 64-66.
[5]	Prasad K, Dash D, Kumar A. Validation of the Hindi version of National Institute of Health Stroke Scale[J]. Neurol India, 2012, 60(1):40-44.
[6]	Mahoney F I, Barthel D W. Functional evaluation: the Barthel index [J]. Maryland State Med J, 1965, 14(14): 61-65.
[7]	周惜珍, 蔡俊东, 江远萍. 丹灯通脑胶囊配合康复训练对老年脑梗死恢复期的影响[J]. 陕西中医, 2016, 37(6): 650-651.
[8]	姜淼, 张凤杰, 佐炳会,等. 黄芪桂枝五物汤辅助治疗对脑梗死恢复期患者的影响[J]. 世界中医药, 2017, 12(7): 1555-1558.
[9]	李志君, 邵宏敏, 张东东,等. 祛痰瘀清热方治疗脑梗死急性期(痰热瘀滞证)的临床观察[J]. 中国中医急症, 2016, 25(7):1428-1429.
[10]	安朋朋, 唐明, 宋永欣,等. 枳实对脑梗死急性期MTL及VIP的调节作用[J]. 中医学报, 2015, 30(10):1461-1463.
[11]	陶茹莹, 张辉. 地龙蛋白和姬松茸多糖的药理研究[J]. 吉林中医药, 2017, 37(7): 706-708.
[12]	曹静, 赵文静, 旺建伟,等. 水蛭的本草考证及现代研究[J]. 中医药信息, 2015, 32(4): 122-124.
[13]	方丽萍, 肖展翅, 柯红艳. 苦碟子注射液对脑梗死恢复期患者血液流变学的影响研究[J]. 实用心脑肺血管病杂志, 2016, 24(3): 93-94.
[14]	Mir I N, Chalak L F. Serum biomarkers to evaluate the integrity of the neurovascular unit [J]. Early Human Develop, 2014, 90(10):707-711.
[15]	吴波. 消栓肠溶胶囊加茴拉西坦治疗对脑梗死康复期患者脑血流灌注、神经功能的影响[J]. 海南医学院学报, 2017, 23(24): 3456-3458, 3462.