腹膜透析患者成纤维细胞生长因子23与股动脉内中膜厚度的相关性

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Abstract Objective To observe the correlations between fibroblast growth factor-23(FGF-23) and femoral artery intima- media thickness(IMT) in peritoneal dialysis patients.Methods Patients on continuous ambulatory peritoneal dialysis(CAPD) were divided into different groups according the femoral artery IMT. The relationships between FGF-23 and femoral artery IMT in different CAPD groups were analyzed.Results The incidence of increased femoral artery IMT in CAPD patients was 45.12%. Age, and levels of serum phosphorous、HbA₁c、intact parathyroid hormone( iPTH) and FGF-23 of the increased IMT group were significantly above those of the normal IMT group (P<0.05). According to multiple logistic regression analysis ,the levels of serum phosphorous、iPTH and a high FGF-23 concentration were significant independent risk factors for increased IMT in CAPD patients(P<0.05).Conclusions These results suggest that a high level of FGF-23 is an important indicator of calcium-phosphorus metabolism and vascular calcification in CKD patients, and maybe an important early warning signal of vascular calcification in CAPD patients.

Key words： peritoneal dialysis fibroblast growth factor- 23 femoral artery intima- media thickness

Received: 27 May 2019

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	Articles by authors
	ZHANG Zhimin
	GAO Feng
	SHI Changqian
	HE Xiao

Cite this article:

ZHANG Zhimin,GAO Feng,SHI Changqian等. Correlations between fibroblast growth factor-23 and femoral artery intima- media thickness in peritoneal dialysis patients[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(11): 948-951.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I11/948

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