长期小剂量口服罗红霉素对慢阻肺患者炎性反应因子的影响

Abstract
Figure/Table
References
Related Citation (13)

Download: PDF (731 KB) HTML (0 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the effect of long-term low dose roxithromycin on inflammatory factors in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 98 patients with COPD admitted to our hospital between January 2016 and May 2018 were selected and equally divided into the combined group and the azithromycin group using the random number table method. The azithromycin group was treated with intravenous infusion of azithromycin, once a day and for three months, while the combined group was additionally given six-month treatment with roxithromycin. The time of remission and disappearance of cough, clinical efficacy and the occurrence of complications were recorded. The sputum volume, dyspnea scores, sputum cytokines Ⅱ interferon (gamma-IFN), interleukin 8 (IL-8), tumor necrosis factor (TNF alpha) levels were compared between the two groups before and after treatment. Results Cough relief and disappearance took much less time in the combined group than in the azithromycin group (P<0.05). The total effective rate of the combined group (95.91%) was significantly higher than that of the azithromycin group (75.51%) (P<0.05). Before treatment, there was no significant difference in sputum volumes and dyspnea scores between the two groups. After treatment, the sputum volume and dyspnea scores of the two groups were significantly reduced, especially in the combined group (P<0.05). Before treatment, there was no significant difference between the two groups in levels of γ - IFN, IL-8 and TNF-α. After treatment, these levels in the two groups were decreased, especially in the combined group (P<0.05). After treatment, PEF,FEV₁ and FEV₁/FVC in the combined group were improved more significantly than in the azithromycin group. Conclusions Long term roxithromycin can reduce airway inflammation, inhibit the levels of inflammatory factors in sputum and improve the lung function of patients with COPD, which is worthy of clinical popularization.

Key words： long term roxithromycin chronic obstructive pulmonary disease airway inflammation pulmonary function

Received: 14 February 2020

ZTFLH:

R563

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WEI Hong
	GONG Wuzhuang
	XIN Jiayin
	ZHAO Na

Cite this article:

WEI Hong,GONG Wuzhuang,XIN Jiayin等. Effects of long-term low dose roxithromycin on inflammatory factors in patients with COPD[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(9): 778-781.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2020/V31/I9/778

[1]	崔学荣.长期口服小剂量红霉素治疗支气管扩张症稳定期患者的疗效[J].医疗装备, 2017,30(21):133-134.
[2]	王文菊,吴晓冬.用小剂量罗红霉素联合氨茶碱治疗支气管扩张的临床疗效观察[J].中国医疗设备,2017,32(S1):94-95.
[3]	芮萌,段蕴铀.慢性阻塞性肺疾病肺康复研究进展[J].武警医学,2020,31(5):441-445.
[4]	Sun X J,Li Z H,Zhang Y,et al.Combination of erythromycin and dexamethasone improves corticosteroid sensitivity induced by CSE through inhibiting PI3K-δ/ Akt pathway and increasing GR expression[J].Am J Physiol Lung Cell Mol Physiol,2015,309(2):L139-L146
[5]	陈畅,曹伟云,廖周旭.长期小剂量罗红霉素口服对支气管扩张症稳定期患者诱导痰IL-6、IL-8 和 IL-10 表达的影响[J].现代医药卫生,2017,33(22):3385-3388.
[6]	中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南[J].中华结核和呼吸杂志,2007,25(8):453-460.
[7]	Sakthivel K M,Guruvayoorappan C.Acacia ferruginea inhibits inflammation by regulating inflammatory i NOS and COX-2[J].Journal of Immunotoxicology,2015,13(1):1-9.
[8]	杨凤霞.小剂量红霉素长期口服佐治支气管扩张症稳定期患者效果评估[J].临床医学研究与实践,2017,2(2):8-9.
[9]	Yang H,Xiang P,Zhang E,et al. Is hypercapnia associated with poor prognosis in chronic obstructive pulmonary disease? A long-term follow-up cohort study[J]. BMJ Open,2015,5(12):e008909
[10]	王永仓,孙晓光,孙砚诚,等.脾氨肽联合小剂量罗红霉素对支气管扩张稳定期疗效观察[J].河北医学,2016,22(2):295-296.
[11]	Marescaux A,Degano B,Soumagne T,et al.Impact of farm modernity on the prevalence of chronic obstructive pulmonary disease in dairy farmers[J].Occup Environ Med,2016,73(2):127-133.
[12]	Liang Q,Ju Y,Yan C,et al. Lymphatic endothelial cells efferent to inflamed joints produce i NOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice[J].Arthritis Research ＆ Therapy,2016,18(1):1-14.
[13]	邓永明.小剂量罗红霉素联合多索茶碱治疗稳定期支气管扩张症的临床效果[J].中国医学前沿杂志,2016,8(7):111-114.
[14]	原芳,李向辉,张爱枝.小剂量红霉素长期口服对支气管扩张症患者感染稳定期链球菌耐药性和氧化应激蛋白的影响[J].东南国防医药,2016,18(5):511-514.
[15]	陈洋,李鑫,王之赫,等.罗红霉素联合氨溴索治疗稳定期支气管扩张症48例疗效观察[J].医学临床研究,2015,32(1):107-109.
[16]	刘英君.小剂量罗红霉素联合氨茶碱治疗支气管扩张的疗效及安全性[J].临床医学研究与实践,2017,2(1):44-45.
[17]	陈宇清,丁凤鸣,李强,等.小剂量阿奇霉素维持治疗对支气管扩张患者肺功能和生命质量的影响[J].中国医师进修杂志,2016,39(6):496-500.
[18]	孙满媛.口服小剂量罗红霉素对支气管扩张长期治疗的临床效果体会[J].当代医学,2016,22(19):146-147.