血清及胎盘中脂蛋白相关磷脂酶A2水平与妊娠期高血压疾病的关系

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Abstract Objective To investigate the relationship between Lp-PLA2 levels in maternal serum and placenta and hypertensive disorders of pregnancy. Methods The levels of Lp-PLA2 in serum and placenta of 60 patients with hypertensive disorders of pregnancy (19 cases of gestational hypertension, 25 cases of mild preeclampsia, and 16 cases of severe preeclampsia) and 20 normal pregnant women (control group) were measured by enzyme-linked immunosorbent assay and immunohistochemistry. The relationship between levels of Lp-PLA2 and hypertensive disorders of pregnancy was analyzed. Results 1) The expression level of Lp-PLA2 in placenta of patients with hypertensive disorders of pregnancy was significantly higher than that of the control group (P<0.05), so was the expression level of Lp-PLA2 in the mild preeclampsia group (P<0.05). The level in the severe preeclampsia group was significantly higher than that of the mild preeclampsia group (P<0.05). 2) The level of maternal serum Lp-PLA2 was significantly higher than that of the control group(P<0.05). With the aggravation of the disease, the level of Lp-PLA2 increased gradually. There was significant difference between the two groups (all P<0.05). 3) There was a positive correlation between the levels of Lp-PLA2 in serum and in placenta of patients with hypertensive disorders of pregnancy (r=0.435, P< 0.05). Conclusions The increase of Lp-PLA2 levels may be related to the occurrence of hypertensive disorders of pregnancy. The change of Lp-PLA2 levels in maternal serum may be used as a monitoring indicator of the disease.

Key words： Lp-PLA2 hypertensive disorders of pregnancy enzyme-linked immuno sorbent assay immunohistochemistry

Received: 10 March 2020

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R714.246

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	Articles by authors
	WANG Jing¹
	DONG Xing²
	ZHANG Xuejun¹
	SHANG Lixin¹

Cite this article:

WANG Jing¹,DONG Xing²,ZHANG Xuejun¹等. Relationship of Lp-PLA2 levels in maternal serum and placenta with hypertensive disorders of pregnancy[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(9): 805-808.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2020/V31/I9/805

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