<sup>68</sup>Ga-PSMA PET-CT与mpMRI显像对前列腺癌淋巴结转移的诊断价值比较

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Abstract Objective To evaluate the diagnostic value of ⁶⁸Ga-PSMA PET/CT and mpMRI in prostate cancer with lymph node metastasis.Methods The Chinese and English databases at home and abroad were searched for diagnostic clinical trials related to ⁶⁸Ga-PSMA PET/CT and mpMRI imaging used for diagnosis of prostate cancer patients with lymph node metastasis. The original data in the literature was retrieved based on patients or lesions. The data was integrated and analyzed by software, including the sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the area under the SROC curve (AUC) of ⁶⁸Ga-PSMA PET/CT and mpMRI imaging in diagnosing prostate cancer with lymph node metastasis.Results A total of 13 eligible articles were included. The patient-based analysis suggested that the SEN, SPE, PLR, NLR, DOR, and AUC of ⁶⁸Ga-PSMA PET/CT for prostate cancer patients with lymph node metastasis were 0.44, 0.93, 5.25, 0.61, 9.67, and 0.90 respectively, while those of mpMRI imaging were 0.44, 0.95, 5.46, 0.62, 12.06 and 0.90 respectively, compared with 0.58, 0.99, 61.22, 0.24, 308.06 and 0.99 with ⁶⁸Ga-PSMA PET/CT, and 0.61, 0.99, 27.17, 0.36, 90.48 and 0.99 with mpMRI imaging when the analysis was based on lymph nodes.Conclusions Both ⁶⁸Ga-PSMA PET/CT and mpMRI imaging have high specificity but poor sensitivity in diagnosing prostate cancer with lymph node metastasis, and mpMRI may be of higher clinical value for the diagnosis of prostate cancer with lymph node metastasis.

Key words： prostate-specific membrane antigen multiparametric magnetic resonance imaging PET/CT prostate cancer lymph node

Received: 03 December 2020

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	HUANG Shiming
	YUE Jianlan
	YIN Liang
	SUN Yongfeng
	LIN Zhichun

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HUANG Shiming,YUE Jianlan,YIN Liang等. A comparison of lymph node staging between ⁶⁸Ga-PSMA PET-CT and mpMRI in patients with prostate cancer[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(4): 320-324.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2021/V32/I4/320

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