老年非酒精性脂肪肝患者25(OH)D<sub>3</sub>水平与胰岛素抵抗、氧化应激的相关性

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Abstract Objective To investigate the changes of serum 25-hydroxyvitamin D₃ (25(OH)D₃) levels in elderly patients with non-alcoholic fatty liver disease (NAFLD) and the relationship between them and insulin resistance and oxidative stress.Methods A total of 125 elderly NAFLD patients treated in our hospital from January 2018 to April 2020 were selected as the observation group and divided into three subgroups according to serum 25(OH)D₃ levels: vitamin D deficiency group, vitamin D insufficiency group and vitamin D normal group;Another 30 elderly healthy subjects were selected as the control group. The serum 25(OH)D₃ level was compared between the observation group and the control group.The differences of body mass index (BMI), blood lipid, liver function, fasting blood glucose (FBG), fasting insulin (FINS), insulin resistance index (HOMA-IR), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) between three subgroups of the observation group were compared. The correlation between serum 25(OH)D₃ level and the above indexes in observation group was analyzed.Results Compared with the control group, the levels of 25 (OH) D₃, SOD and GSH-Px in the observation group were significantly decreased, and the levels of BMI, FINS, HOMA-IR and MDA were significantly increased (P<0.05). Compared with vitamin D normal group, the levels of FINS, HOMA-IR and MDA in vitamin D deficiency group and vitamin D insufficiency group were significantly increased, while the levels of SOD and GSH-Px were significantly decreased (P<0.05); The levels of each index in vitamin D deficiency group were higher or lower than those in vitamin D insufficiency group (P<0.05). 25 (OH) D₃ level was significantly negatively correlated with HOMA-IR and MDA (r=-0.395, r=-0.328, all P<0.05), and positively correlated with SOD and GSH-Px In the observation group (r=0.388, r=0.376, all P<0.05).Conclusions The level of serum 25(OH)D₃ in elderly patients with NAFLD decreased significantly, and the deficiency of serum 25(OH)D₃ was closely related to insulin resistance and oxidative stress.

Key words： non-alcoholic fatty liver disease 25 hydroxyvitamin D₃ insulin resistance oxidative stress

Received: 12 March 2020

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	XIE Wenxiu
	ZHANG Chunyan
	YU Xiaohong

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XIE Wenxiu,ZHANG Chunyan,YU Xiaohong. Relationship between 25 (OH) D₃ level and oxidative stress and insulin resistance in elderly patients with nonalcoholic fatty liver disease[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(6): 513-517.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2021/V32/I6/513

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