细菌感染性肺炎患儿血清PCT、hs-CRP、WBC、IL-6、Hb与病情严重程度的相关性分析

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (690 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the correlation between serum procalcitonin ( PCT), serum high-sensitivity-reactive protein(hs-CRP), white blood cells(WBC), interleukin-6 (IL-6), hemoglobin (Hb) level changes and the severity of bacterial infectious pneumonia in children.Methods Ninety-eight children with bacterial infectious pneumonia admitted to our hospital from March 2019 to March 2021 were selected as the study subjects, and another 98 children with health examination during the same period were selected as the control group. Continuous variables were evaluated according to the clinical lung infection scores and divided into severe and mild groups, and the association between serum PCT, hs-CRP, WBC, IL-6, and Hb and disease severity was analyzed using statistical software. Serum from all subjects was collected for analysis, and the data showed that the levels of PCT, hs-CRP, WBC and IL-6 in the study group compared with the control group.Results The expression of PCT(μg/ml) in the control group (0.27±0.12) <mild group (1.98±0.43) <severe group (2.04±0.45); the hs-CRP (mg/L) expression in the control group (5.64±2.37) <mild group (21.27±9.13) <severe group (26.84±9.32); the expression of WBC (×10⁹/L) in the control group (10.46±2.95) <mild group (23.05±3.79) <severe group (26.27±5.21); the expression of IL-6(pg/L) in the control group (10.23±2.46) <mild group (62.45±9.43) <severe group (96.43±12.03); the expression of Hb(g/L) in the severe group (123.43±14.85) <mild group (126.58±16.53) <control group (135.24±14.74).The difference was statistically significant (P＜0.05).Moreover, with a positive correlation with the severity of the disease, the r-values of PCT, hs-CRP, WBC, IL-6, and Hb were 0.085,0.910,0.941,0.957, and -0.738, respectively. According to the Logistic regression model analysis, PCT, hs-CRP, WBC, IL-6, and Hb were the independent risk factors affecting the disease progression of children with bacterial infectious pneumonia (P<0.05).Conclusions Serum PCT, hs-CRP, WBC, IL-6 and Hb are related with the serious condition of children with bacterial infectious pneumonia, which can provide diagnostic basis for combined diagnostic indicators for early bacterial infectious pneumonia in children.

Key words： bacterial infection pneumonia serum index correlation

Received: 24 November 2021

ZTFLH:

R563.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LUO Yun

Cite this article:

LUO Yun. Correlation analysis of serum PCT, Hs-CRP, WBC, IL-6, Hb and disease severity in children with bacterial infection pneumonia[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(4): 277-280.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I4/277

[1]	刘新华,林小勇,冯永胜.外周血白细胞、C反应蛋白、降钙素原在新生儿感染性肺炎诊断中的应用价值分析[J].中国现代药物应用,2021,15(15):45-47.
[2]	杨浩然,张学勤.细菌感染性肺炎患儿胸部CT征象及其与患儿肺部炎性情况、预后的关系[J].影像科学与光化学,2021,39(5):705-710.
[3]	陈墩顺,黄晓颖.注射用头孢哌酮钠舒巴坦钠联合噻托溴铵粉吸入剂对支气管扩张患者的临床效果[J].中国生化药物杂志,2016,36(7):79-81.
[4]	卢运照,韦晓珍,潘雅芳.C-反应蛋白与前白蛋白比值、T淋巴细胞亚群在新生儿细菌感染性肺炎中的变化及其相关性[J].湖南师范大学学报(医学版),2021,18(2):226-229.
[5]	郭倩,李金红,张岩岩,等.IL-25、TSLP在细菌感染性肺炎患儿血清中表达水平及其与免疫炎性的相关性[J].热带医学杂志,2021,21(8):1030-1034.
[6]	禹露,李小峰.SAA、PCT和CRP联合检测在新生儿感染性肺炎诊断中的临床价值分析[J].临床医学工程,2021,28(5):657-658.
[7]	江载芳,申昆玲,沈颖. 诸福棠实用儿科学(第8版)[M]. 北京:人民卫生出版社,2015.
[8]	郭磊,丁效国,杨丽.肺炎支原体合并细菌感染患儿C反应蛋白、降钙素原及白介素-6的变化及临床意义[J].兵团医学,2021,19(2):13-15.
[9]	张瑞,支素芳,刘金广,等.小儿支气管肺炎病原菌分布及降钙素原、超敏C反应蛋白诊断价值[J].临床军医杂志,2021,49(02):164-165,168.
[10]	容立炽.分析小儿感染性肺炎诊断中血清降钙素原与C反应蛋白联合检测的效果及临床价值[J].智慧健康,2020,6(35):26-27,39.
[11]	胡忠华,吕银江,毛月燕,等.血清降钙素原、γ-干扰素及T淋巴细胞水平与感染性肺炎新生儿病情严重程度的关系[J].中国妇幼保健,2020,35(19):3617-3620.
[12]	邓宇涛,吴丽,梁映亮,等.纤维蛋白原,降钙素原,超敏C反应蛋白以及白细胞计数检测在评判儿童是否为细菌感染肺炎中的应用价值[J].中医临床研究,2020,12(23):31-33.
[13]	黄美霞, 郑燕, 潘丹峰,等. 血浆D-二聚体水平与儿童肺炎支原体肺炎疾病严重度及预后的相关性研究[J]. 四川大学学报(医学版), 2022, 53(1):160.
[14]	尹琳琳,朱一堂,王文龙.降钙素原、C反应蛋白、血清淀粉样蛋白A在儿童细菌性与非细菌性医院获得性肺炎中的鉴别诊断价值[J/OL].医学综述,2022(2):406-410,416.
[15]	赵贺红,曹丽敏,董凤芝.咽拭子培养联合降钙素原、C反应蛋白及肺炎支原体检测在儿童肺炎诊断中的应用[J].中国医学工程,2021,29(12):73-76.
[16]	王新,王佳美,孙雨婷.全血C反应蛋白和白细胞计数在儿科细菌性肺炎中的应用价值[J].中国实用医药,2021,16(36):48-50.
[17]	孙晓舟,徐炎,王丹丹,等.清肺饮调节TLR4/NF-κB炎性信号通路治疗细菌性肺炎的作用机制[J].中国中医基础医学杂志,2021,27(11):1738-1744.
[18]	徐超,李超,蒋勇.CD64、P2X7和cMPO检测在小儿细菌性肺炎诊断及预后中的研究[J].分子诊断与治疗杂志,2021,13(9):1461-1464.
[19]	祝体红,赵勇,许玉峰.血清PCT、α1-AT、HMGB1水平对新生儿细菌性肺炎的鉴别诊断[J].分子诊断与治疗杂志,2021,13(8):1264-1267.
[20]	李晓红.儿童细菌性肺炎血清降钙素原与血培养检测临床意义比较[J].医学食疗与健康,2021,19(9):154-155.