夫西地酸乳膏联合复方丙酸氯倍他索软膏治疗手足角化性湿疹的疗效研究

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Abstract Objective To analyze the effect of fusidic acid ointment combined with compound clobetasol propionate ointment in the treatment of hand and foot keratotic eczema.Methods Eighty patients with hand-foot keratotic eczema admitted to the Third Medical Center of PLA General Hospital were randomly divided into a control group (42 cases) and an observation group (42 cases). The control group was treated with compound clobetasol propionate ointment, while the observation group was treated with fusidic acid ointment combined with compound clobetasol propionate ointment. The course of treatment lasted for 4 weeks. The pruritus, eczema area and severity index(EASI) ,dermatological quality of life scale (DLQI) scores, inflammatory factors IL-2、IL-4、IL-5 and TNF-αwere compared between the two groups before and after 4 weeks of treatment, and the efficacy and safety of the two groups were also evaluated.Results The effective rate of treatment in the observation group was 88.10%, which was higher than 71.43% in the control group (P<0.05). After 4 weeks, the observation group's pruritus scores[(1.12±0.26)], EASI scores[(3.25±0.77)]and DLQI scores[(16.34±3.28)]were all lower than those of the control group[respectively(1.44±0.38),(5.33±1.12) and(18.78±3.67)] (P<0.05). Inflammatory factors IL-2, IL-4, IL-5 and TNF-α in the observation group were also lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (9.52% vs. 4.76%).Conclusions Fusidic acid ointment combined with compound clobetasol propionate ointment in the treatment of hand and foot keratotic eczema, which can reduce allergy and inflammation and can also reduce itching significantly, is effective and safe.

Key words： hand and foot keratotic eczema fusidic acid ointment compound clobetasol propionate ointment

Received: 15 January 2022

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R758.23

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	Articles by authors
	SHU Xin
	TU Xiaojuan
	CHEN Xiaoxia
	ZHANG Wei
	YANG Yina
	ZHENG Jiao

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SHU Xin,TU Xiaojuan,CHEN Xiaoxia等. Effect of fusidic acid ointment combined with compound clobetasol propionate ointment in treatment of hand and foot keratotic eczema[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(6): 518-521.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I6/518

[1]	赵辨.中国临床皮肤病学[M]. 2版.南京:江苏凤凰科学技术出版社,2017:760.
[2]	Agner T,Aalto-Korte K, Andersen K E, et al. Factors associated with combined hand and foot eczema[J].J Eur Acad Dermatol Venereol, 2017, 31(5): 828-832.
[3]	Yamada K, Matsushita K, Wang J, et al. Topical glucose induces caudin-1 and filaggrin expression in a mouse model of atopic dermatitis and in keratinocyte culture, exerting anti-inflammatory effects by repairing skin barrier function[J]. Acta Derm Venereol,2018,98(1):19-25.
[4]	Rademaker M,Armour K,Baker C, et al.Management of chronic hand and foot eczema. An Australia/New Zealand Clinical narrative[J]. Australas J Dermatol, 2021,62(1):17-26
[5]	余艺昕,杨斌.手湿疹中外诊疗指南概述[J].中华皮肤科杂志,2019,52(1):53-56.
[6]	Bartosíková L, Frána L, Necas J, et al. Prednicarbate and cetirizin dihydrochloride in the treatment of atopic eczema in the acute phase in children[J]. Ceska Slov Farm, 2018, 50(1): 38-40.
[7]	Bonamonte D, Belloni Fortina A, Neri L, et al. Fusidic acid in skin infections and infected atopic eczema[J]. G Ital Dermatol Venereol, 2014, 149(4): 453-459.
[8]	郑筱萸.中药新药临床研究[M].北京:中国医药出版社,2002:144-146.
[9]	舒心,周喻,陈晓霞,等.银屑病患者生活质量和心理健康状况调查及其影响因素分析[J].武警医学,2021,32(2):132-35.
[10]	Elsner P, Agner T. Hand eczema: treatment[J]. J Eur Acad Dermatol Venereol, 2020, 34(Suppl 1):13-21.
[11]	Coenraads P J. Hand eczema[J]. N Engl J Med. 2012, 367(19):1829-1837.
[12]	Agrawal P V, Sharma Y K,Kumar A, et al. Comparative analysis of epidemiological data as well as quality of life in patients having hand eczema vis-à-vis foot eczema[J]. Indian Dermatol Online J, 2019, 10(5): 519-523.
[13]	杨军,毕鸣晔.复方丙酸氯倍他索软膏联合5%水杨酸软膏外用治疗慢性湿疹疗效观察[J].实用皮肤病学杂志,2016,9(3):180-182.
[14]	丁蓉.夫西地酸乳膏联合卤米松乳膏治疗慢性湿疹疗效研究[J].现代实用医学,2014,26(1),102-103.
[15]	Takeuchi A, Oguri T, Sone K, et al. Predictive and prognostic value of CYFRA 21-1 for advanced non-small cell lung cancer treated with EGFR-TKIs[J]. Anticancer Res, 2017, 37(10):5771-5776.
[16]	邓晶晶.针刺联合穴位自血疗法治疗慢性湿疹的临床研究[J]. 针灸临床杂志,2018,34(1) : 15-18.
[17]	Tsoi L C, Rodriguez E, Stölzl D, et al. Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses[J]. J Allergy Clin Immunol, 2020, 145(5): 1406-1415.
[18]	Wang S, Zhu R, Gu C, et al. Distinct clinical features and serum cytokine pattern of elderly atopic dermatitis in China[J]. J Eur Acad Dermatol Venereol, 2020,34(10):2346-2352.
[19]	胡慧营,程广杰,梁庆伟,等.清热去湿汤对急性湿疹(湿热证)患者外周血Th1/Th2细胞因子水平的影响[J]. 中国中医急症,2021, 30(7):1285-1287.