老年轻度血管性认知障碍患者血清C-反应蛋白和白细胞介素-6水平与抑郁情绪的相关性

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Abstract Objective To investigate the association between depression and the serum C-reactive protein and Interleukin-6 in elderly patients with mild vascular cognitive impairment (mVCI).Methods Case-control studies were used. A total of 82 elderly patients with mild vascular cognitive impairment were enrolled in Shaanxi Provincial Corps Hospital of Chinese People’s Armed Police Force from March 2021 to June 2022. According to the testing standard score of Self-Rating Depression Scale, the patients were divided into 2 groups of the depressed mood group and the no-depressed mood group. During the same period, 76 people with normal physical examination results in physical examination center were classified into the control group. The serum CRP and IL-6 levels were detected and the data were analyzed statistically.Results The serum CRP levels in the case group and in the control group were respectively(7.16±2.57)mg/L and(4.28±2.11)mg/L,IL-6 were respectively(7.43±1.81)pg/ml and(5.31±1.67)pg/ml, and there were statistical differences between the two groups(t=-7.664,P＜0.001;t=-7.688,P＜0.001).The serum CRP levels in the depressed group and in the control group were respectively(7.41±2.34)mg/L and(6.10±2.13)mg/L,IL-6 were respectively(7.67±1.76)pg/ml and(6.90±1.35)pg/ml, and there were also statistical differences between the two groups(t=2.642,P＜0.05;t=2.205,P＜0.05).Conclusions For elderly mVCI patients, attention should be paid to monitoring the levels of CRP and IL-6, which has certain guiding significance for the early diagnosis and intervention of patients with obscure depressive mood.

Key words： cognition depression C-reactive protein interleukin-6

Received: 20 January 2023

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	QUAN Qingyun
	YU Li
	HUANG He

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QUAN Qingyun,YU Li,HUANG He. Correlation between serum C-reactive protein and Interleukin-6 levels and depressive in elderly patients with mild vascular cognitive impairment[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(5): 407-409.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2023/V34/I5/407

[1]	Hachinski V C,Bowier J V. Vascular dementia [J]. Nenrology,1993, 43(10): 2159-2160.
[2]	中国医师协会神经内科分会认知障碍专业委员会《中国血管性认知障碍诊疗指南》编写组.2019年中国血管性认知障碍诊治指南[J].中华医学杂志,2019, 99(35): 2737-2744.
[3]	van Rijsbergen M W A, Mark R E, Kop W J,et al.Psychological factors and subjective cognitive complaints after stroke:beyond depression and anxiety[J].Neuropsychol Rehabil, 2018, 29(10): 1671-1684.
[4]	赵羚,孙文悦,刘金玲等. 老年血管性认知功能障碍患者MOCA评分与焦虑、抑郁的相关性[J]. 中国老年学杂志,2020, 40(22): 4810-4812.
[5]	Li N, Chen G, Zeng P, et al. Prevalence and factors associated with mild cognitive impairment among Chinese older adults with depression[J]. Geriatr Gerontolint, 2018, 18(2): 263-268.
[6]	王锦秀,王剑涛,胡月,等. 抑郁和焦虑与老年认知障碍患者认知水平的相关性分析[J].中国临床医学,2022, 29(4): 536-543.
[7]	地力木拉提·阿米提,张士勇,李冬梅. 乌鲁木齐地区轻度认知障碍合并2型糖尿病患者抑郁情绪的发生及其影响因素分析[J]. 武警医学,2011, 22(1): 8-11.
[8]	Barnes J, Mondelli V, Pariante C M. Genetic contributions of inflammation to depression [J].Neuropsychopharmacology, 2017, 42(1): 81-98.
[9]	Paroni G, Panza F, Decosmo S, et al. Klotho at the edge of Alzheimer's disease and senile depression [J]. Mol neurobiol, 2019, 5(63): 1908-1920.
[10]	An X L, Li C L. Analysis of risk factors for vascular cognitive impairment in patients with cerebral infarction [J]. Cell Biochem Biophys,2015, 71(2): 673-677.
[11]	Roomruangwong C, Kanchanatawan B, Sirivichayakul S,et al.Lower serum zinc and higher CRP strongly predict prenatal depression and physiosomatic symptoms,which all together predict postnatal depressive symptoms[J].Mol Neurobiol, 2017, 54(2): 1500-1512.
[12]	Wu S Q, Liao Q C, Xu X X, et al. Effect of CPAP therapy on C-reactive protein and cognitive impairment in patients with obstrutive sleep apnea hypopnea syndrome[J]. Sleep Breath, 2016, 20(4): 1185-1192.
[13]	Zadka Ł, Dzięgiel P, Kulus M, et al.Clinical phenotype of depression affects interleukin-6 synthesis[J].J Interferon Cytokine Res, 2017, 37(6): 231-245.
[14]	Ma L, Demin K A, Kolesnikova T O, et al.Animal inflammation based models of depression and their application to drug discovery [J].Expert Opin Drug Discov, 2017, 12(10): 995-1009.
[15]	胡楠楠,孙继军. 老年抑郁症患者神经递质炎症因子水平与认知功能的关系[J].中国老年学杂志,2020, 40(12): 2604-2606.
[16]	孟军鹏,孟林. 颈动脉支架植入术对症状性颈动脉狭窄患者血清炎症因子及认知功能影响的临床研究[J].陕西医学杂志,2020, 49(7): 796-799.
[17]	Schmidt R, Schmidt H, Curb J D, et al. Early inflammation and dementia: a 25-year follow-up the Honolulu-Asia Aging Study [J]. Ann Neurol, 2002, 52(2): 168-174.