NT-proBNP与可溶性ST2评估妊娠合并心脏病患者心功能的价值

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Abstract Objective To analyze the value of NT- proBNP and soluble ST2 in the evaluation of cardiac function in pregnant women with heart disease. Methods Data analysis was performed on 228 patients with heart disease who were hospitalized in the obstetrics ward and gynecology department of the General Hospital of PLA Northern Theater from January 2017 to December 2021 by SPSS21.0 statistical software. Results Congenital heart disease was the main symptom in 145 cases, accounting for 63.6%, followed by arrhythmia (78 cases, 34.2%) and others (5 cases, 2.2%);The patients were divided into groups according to cardiac function grades Ⅰ, Ⅱ, Ⅲ and Ⅳ, and the plasma NT-proBNP and soluble ST2 concentrations were compared at admission. It was found that the concentration of NT-proBNP and soluble ST2 in grade Ⅰ and grade Ⅱ groups was significantly different from that in groups of grade Ⅲ to Ⅳ, respectively (P<0.05). However, there was no significant difference in the concentration of NT-proBNP between group Ⅰ and group Ⅱ (P>0.05), and there was significant difference in the concentration of soluble ST2 between group Ⅰ and group Ⅱ (P<0.05). The concentration of NT-proBNP and soluble ST2 in plasma was compared between congenital heart disease group and arrhythmia group. There was no statistically significant difference in the concentration of NT proBNP and soluble ST2 in the grade I group (P>0.05), and no statistically significant difference in the concentration of NT proBNP in the grade Ⅱ group (P>0.05). The concentration of soluble ST2 in grade Ⅱ group was statistically significant (P<0.05), and the concentration of NT-proBNP and soluble ST2 between the grade Ⅲ-Ⅳ groups was statistically significant (P<0.05). Conclusions The concentration of plasma NT proBNP and soluble ST2 is of great value in assessing cardiac function in pregnant patients with cardiac disease. The concentration of soluble ST2 has a close correlation with cardiac functional grades and the degree of heart failure, and the specificity is strong.

Key words： pregnancy with heart disease NT-proBNP soluble ST2 significance

Received: 16 December 2022

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	HONG Yan
	QV Dongying
	LI Hongfei

Cite this article:

HONG Yan,QV Dongying,LI Hongfei. Value of NT proBNP and soluble ST2 in evaluating cardiac function in pregnant women with heart disease[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(12): 1042-1045.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2023/V34/I12/1042

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