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| Effect of local infusion of budesonide combined with acetylcysteine in treatment of severe pneumonia in children after bronchoalveolar lavage |
| LIU Ruihua, TIAN Chen, YAN Yan, ZHANG Jingjing |
| Department of Pediatrics, Characteristics Medical Center of Chinese People's Armed Police Force, Tianjin 300162, China |
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Abstract Objective To investigate the effect of local perfusion of budesonide combined with acetylcysteine in the treatment of severe pneumonia in children after electronic bronchoscopic alveolar lavage (BAL). Methods A total of 74 children with severe pneumonia admitted to the Pediatric Department of Characteristics Medical Center of Chinese People's Armed Police Force from September 2023 to August 2024 were selected and divided into an observation group (n=37) and a control group (n=37). On the basis of conventional treatment, the control group was treated with 0.9% NaCl alveolar lavage using electronic bronchoscopy, while the observation group was treated with local infusion of budesonide combined with acetylcysteine in addition to the control group. The clinical efficacy, cough disappearance time, body temperature recovery time, inflammatory indicators, hospitalization time, and incidence of adverse reactions were observed respectively in the two groups. Results The clinical efficacy, inflammatory indicators, and hospitalization stay of the observation group were significantly better than those of the control group, with statistically significant difference (P<0.05). There was no statistically significant difference in the recovery time of body temperature, disappearance time of cough, and incidence of adverse reactions between the two groups. Conclusions Local infusion of budesonide combined with acetylcysteine after alveolar lavage is characterized by significant clinical effect in the treatment of children with severe pneumonia, which can accelerate the absorption of pulmonary inflammatory lesions, shorten the length of hospital stay and reduce inflammatory indicators.
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Received: 10 September 2024
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2025, Vol. 36 
