Abstract：Objective To study the effects of combined leflunomide and cozaar therapy on IgA nephropathy. Methods Forty patients with IgA nephropathy diagnosed by renal biopsy were randomly divided into two groups: cozaar (100 mg/d) treated group and leflunomide(20mg/d) plus cozaar treated group. The changes in proteinuria and serum creatinine were observed. Results After 1 month treatment by the two methods, the level of proteinuria decreased significantly ［(0.92±0.53) vs (1.28±0.99)］（P <0.05）in all.After 3 and 6 months of treatment , the level of proteinuria in combined leflunomide and cozaar therapy group was lower than that in cozaar therapy group（P<0.05）. Conclusions Combined leflunomide and cozaar therapy reduces 24 h urine proteinuria and protects renal function in patients with IgA nephropathy.
2012, Vol. 23 
