Effect of integrated candesartan cilexetil tablets and acteoside capsules on microalbuminuria in patients with early diabetic nephropathy
XUE Fuping1,YUAN Huixin2,GUO Lijun3,and MA Dong4.
1. Department of Nephrology, 2.The Central Hospital, 3. Department of Endocrinology, 4. Department of Cardiology, Shanxi Provincial Corps Hospital of Chinese People’s Armed Police Forces,Taiyuan 030001,China
Abstract：Objective To study the effect of integrated candesartan cilexetil tablets and acteoside capsules on microalbuminuria in patients with early diabetic nephropathy. Methods Fifty-six patients with early diabetic nephropathy were recruited and randomly divided into two groups, the single group and the integrated group. In the single group, 28 cases were treated with candesartan cilexetil tablets (4 mg穚o穛d );in the integrated group,28 cases were treated with integrated candesartan cilexetil tablets(4 mg穚o穊id) and acteoside capsules (0.4 g穚o穊id). BP(blood pressure), FBG(fasting blood glucose),2hFBG(2-hour postprandial blood glucose), Bun,Scr, SCys-C and UMA were examined before and after treatment.Results There was no statistically significant difference between the two groups before treatment. After treatment, Cys-C and UMA were lower than that before treatment in both groups (P<0.01), and were remarkably reduced in the integrated group contrasted with the single group (P<0.01). Conclusions Integrated candesartan cilexetil tablets and acteoside capsules have no remarkable influence in BP, BG, Bun and Scr, but efficiently decrease the SCys-C and UMA in patients with early diabetic nephropathy.So the onset of clinical proteinuria can be delayed and the renal function can be protected.
薛福平,袁慧欣,郭丽君,马冬. 坎地沙坦脂联合地黄叶总苷治疗早期糖尿病肾病疗效观察[J]. , 2013, 24(10): 857-859.
XUE Fuping,YUAN Huixin,GUO Lijun,and MA Dong. . Effect of integrated candesartan cilexetil tablets and acteoside capsules on microalbuminuria in patients with early diabetic nephropathy. , 2013, 24(10): 857-859.
2013, Vol. 24 
