Abstract：Objective Chemerin is a newly discovered adipokine. This aim of the study was to determine the association of serum chemerin levels with the development of type 2 diabetes mellitus accompanied by coronary artery disease. Methods This study consisted of 256 patients with type 2 diabetes mellitus: 156 without coronary artery disease and 100 with coronary artery disease. Serum chemerin levels were investigated in the two groups by enzyme-linked immunosorbent assay. Multivariable logistic regression analysis was used to analyze the correlation between type 2 diabetes mellitus and the coronary artery disease. Results Type 2 diabetes mellitus patients with combined coronary artery disease showed significantly elevated serum chemerin levels compared with those without coronary artery disease. Serum chemerin level was a determinant parameter of the presence of coronary artery disease in type 2 diabetes mellitus patients. Conclusions Serum chemerin level can serve as a predictive serum marker for the development of coronary artery disease in type 2 diabetes mellitus patients.
Zellweger M J. Prognostic significance of silent coronary artery disease in type 2 diabetes[J]. Herz, 2006, 31(3):240-245.
[2]
Cirillo P1, Di Palma V, Maresca F, et al. The adipokine visfatin induces tissue factor expression in human coronary artery endothelial cells: another piece in the adipokines puzzle [J]. Thromb Res, 2012, 130(3):403-408.
[1]
Zellweger M J. Prognostic significance of silent coronary artery disease in type 2 diabetes[J]. Herz, 2006, 31(3):240-245.
[2]
Cirillo P1, Di Palma V, Maresca F, et al. The adipokine visfatin induces tissue factor expression in human coronary artery endothelial cells: another piece in the adipokines puzzle [J]. Thromb Res, 2012, 130(3):403-408.
[3]
Harwood H J Jr. The adipocyte as an endocrine organ in the regulation of metabolic homeostasis [J]. Neuropharmacology, 2012, 63(1):57-75.
[3]
Harwood H J Jr. The adipocyte as an endocrine organ in the regulation of metabolic homeostasis [J]. Neuropharmacology, 2012, 63(1):57-75.
[4]
Kolasa-Trela R1, Miszalski-Jamka T, Grudzień G, et al. Adiponectin, leptin, and resistin in patients with aortic stenosis without concomitant atherosclerotic vascular disease [J]. Pol Arch Med Wewn, 2011, 121(10):352-359.
[4]
Kolasa-Trela R1, Miszalski-Jamka T, Grudzień G, et al. Adiponectin, leptin, and resistin in patients with aortic stenosis without concomitant atherosclerotic vascular disease [J]. Pol Arch Med Wewn, 2011, 121(10):352-359.
[5]
Lin X, Tang X, Jiang Q, et al. Elevated serum Chemerin levels are associated with the presence of coronary artery disease in patients with type 2 diabetes [J]. Clin Lab, 2012, 58(5-6):539-544.
[5]
Lin X, Tang X, Jiang Q, et al. Elevated serum Chemerin levels are associated with the presence of coronary artery disease in patients with type 2 diabetes [J]. Clin Lab, 2012, 58(5-6):539-544.
[6]
Berg V, Sveinbjrnsson B, Bendiksen S, et al. Human articular chondrocytes express ChemR23 and Chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand Chemerin(21-157) [J]. Arthritis Res Ther, 2010, 12(6):R228.
[7]
Kaur J, Adya R, Tan B K, et al. Identification of Chemerin receptor (ChemR23) in human endothelial cells: Chemerin-induced endothelial angiogenesis [J]. Biochem Biophys Res Commun, 2010, 391(4):1762-1768.
Berg V, Sveinbjrnsson B, Bendiksen S, et al. Human articular chondrocytes express ChemR23 and Chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand Chemerin(21-157) [J]. Arthritis Res Ther, 2010, 12(6):R228.
[7]
Kaur J, Adya R, Tan B K, et al. Identification of Chemerin receptor (ChemR23) in human endothelial cells: Chemerin-induced endothelial angiogenesis [J]. Biochem Biophys Res Commun, 2010, 391(4):1762-1768.
2014, Vol. 25 
