Association between ADAM33 V4 polymorphsim and susceptibility in childhood asthma: a meta-analysis
LI Xin1,2, LI Hongbin3, JIN Yan4, and HAO Donglan4
1. Departent of Oncology, Renai Hospital of Dengzhou, Dengzhou 474100,China; 2. Department of Interventional Ultrasound, Chinese PLA Hospital, Beijing 100853, China; 3. School of Public Health, Xinxiang Medical University, Xinxiang 453003, China; 4. Department of Ultrasound, Central Hospital of Dengzhou, Dengzhou 474100, China
Abstract：Objective To study whether the polymorphisms of V4 in ADAM33 (A Disintegrin and Metalloproteinase 33) gene contribute to the susceptibility to childhood asthma. Methods According to the same criteria, all the clinical studies related to the polymorphism of ADAM33 gene and asthma were searched through PubMed, Ovid-Medline, Embase、CNKI, Wanfang and Weipu databases. All retrieved articles were screened and evaluated followed by meta-analysis using RevMan 5 software. Results Six studies were included based on the selection criteria. In these studies, 1435 childhood asthma and 1710 controls were identified and all control group genotype frequencies were consistent with Hardy-Weinberg equilibrium. By meta-analysis, in allele and dominant models and recessive models,ADAM33 gene V4 polymorphism was not related to liability of childhood asthma (G与C:OR=1.33,95%CI=0.96-1.84,P=0.09;CG+GG与CC:OR=1.41,95%CI=0.95-2.08,P=0.09;CC+CG与GG:OR=0.47,95%CI=0.18-1.22,P=0.12). Conclusion Polymorphism of ADAM33 V4 seems not to be involved in elevated risk of childhood asthma.
李鑫,李宏彬,金燕,郝冬兰. ADAM33基因V4位点多态性与儿童哮喘易感性的关系[J]. 武警医学, 2015, 26(11): 1134-1136.
LI Xin, LI Hongbin, JIN Yan, and HAO Donglan. Association between ADAM33 V4 polymorphsim and susceptibility in childhood asthma: a meta-analysis. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(11): 1134-1136.
Chi X, Wang L, Wang J,et al. Association of ADAM33 gene polymorphisms with asthma in a Chinese population [J]. Clin Respir J, 2013, 7(1): 16-20.
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2015, Vol. 26 
