Application of serum CRP and PCT to diagnosis of infantile acute appendicitis
WANG Yanjun1, LEI Haiyun2, and ZHANG Xiaoli3
1.Department of Clinical Laboratory, Xinjiang Production and Construction Corps Hospital, People’s Armed Police Force,Urumqi 830063,China; 2.Department of Clinical Laboratory, People’s Hospital of Shuimogou District, Urumqi 830063, China; 3.General Hospital of Chinese People’s Armed Police Force,Beijing100039, China
Abstract：Objective To investigate the clinical applicability of serum CRP and PCT in the diagnosis of infantile acute appendicitis.Methods Ninety-six children diagnosed with acute appendicitis were recruited in the experimental group, while fifty-six healthy children who were subjected to a physical examination at the same time were selected in the control group.The levels of serum CRP, PCT, NEUT% and WBC were detected respectively. The specificityand sensitivity of PCT and CRP in the experimental group were statistically analyzed.Results The levels of serum CRP(27.73±6.77)mg/L,PCT(1.78±0.86)μg/L,NEUT%(80.63±10.35)% and WBC(14.20±3.21)×109/L in the experimental group were significantly higher than those in the control group(4.17±1.36)mg/L,(0.43±0.76)μg/, (63.45±7.3)and(9.07±3.59)×109/L respectively. The levels of serum CRP and PCT were significantly different between different groups of appendicitis(P<0.05). The sensitivity and specificity of CRP were 71.9% and 88.5% respectively, while those of PCT were 85.4% and 90.6% respectively. The difference in sensitivity was of no statistical significance, but the difference in specificity was(P<0.01).Conclusions The detection of serum CRP and PCT levels is of some clinical value in diagnosis of infantile acute appendicitis. As the PCT level has a high sensitivity and specificity, it can serve better as an auxiliary diagnostic indicator for appendicitis.
王艳军, 雷海云, 张小丽. 血清C反应蛋白和降钙素原对小儿急性阑尾炎的诊断价值[J]. 武警医学, 2016, 27(12): 1218-1220.
WANG Yanjun, LEI Haiyun, and ZHANG Xiaoli. Application of serum CRP and PCT to diagnosis of infantile acute appendicitis. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(12): 1218-1220.
Gavela T, Cabeza B, Serrano A, et al. C-reactive protein and procalcitonin are predictors of the severity of acute appendicitis in children[J]. PEDIATR EMERG CARE, 2012, 28(5): 416-419.
2016, Vol. 27 
