Correlations between plasma NT-ProBNP, hs-CRP and serum IL-10 levels and heart function in elderly patients with chronic heart failure
WEN Fangmei1, SHAN Zimei2, and GAO Shuang3
1.Department of The First Gerontotherapeutics, 2.Cadre Ward Care Center,Xinjiang Municipal People’s Hospital,Urumqi 830001,China. 3. Xinjiang Municipal Corps Hospital of Chinese People’s Armed police Force, Urumqi 830091,China
Abstract：Objective To study the clinical correlations between plasma NT-ProBNP, hs-CRP and serum IL-10 levels and the heart function in elderly patients with chronic heart failure.Methods 79 elderly patients with chronic heart failure treated in this hospital from November 2014 to December 2015 were recruited as study group,another 45 healthy volunteers as control group.The cardiac function,IL-10,hs-CRP and NT-ProBNP indexes of patients in the two groups were detected by Doppler ultrasonography,enzyme linked immunosorbent assay,immunoassay and colloidal gold Methods.Results In the study group,35 patrents had normal cardiac systolic function, and the other 44 patients had systolic dysfunction.The NT-ProBNP, hs-CRP levels in the normal cardiac systolic function group and systolic dysfunction group were significantly higher than those in the control group,while the IL-10 level was significantly lower;the difference was statistically significant between the 3 groups(P＜0.05).The NT-ProBNP and hs-CRP levels of different cardiac function classification in the study group were significantly higher than those in the control group,while the IL-10 level was significantly lower;the difference was statistically significant between the 4 groups(P＜0.05). The NT-ProBNP and hs-CRP levels were positively correlated with the cardiac functional grading(P＜0.05), while there was a negative correlation between the IL-10 level and the cardiac functional grading(P＜0.05).Conclusions The levels of plasma NT-ProBNP, hs-CRP and serum IL-10 are obviously correlated with cardiac function in elderly patients with chronic heart failure,which can be used as an important indicator for clinical diagnosis and disease evaluation.
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2016, Vol. 27 
