Abstract：Objective To analyze the consumption of antibiotics and resistant situation of antimicrobics isolated during January 2013- December 2015 from a Beijing Tertiary Hospital, which could be helpful for the clinical doctors to use antibacterial agents rationally and control the growth of bacterial resistance.Methods The defined daily dose (DDD) method were used to survey the hospital bacteria resistant situation and the antibacterial consumption for inpatients from January 2013 to December 2015. The type of antibacterial agents, the stock-out amount and the amount of money were collected and analyzed retrospectively by the hospital computer management software.Results In the past three years,the consumption of penicillin, cephalosporins, aminoglycoside, and fluoroquinolones showed varying degrees of decline, but, the usage of carbapenems antibiotics and cephalosporin+enzyme inhibitor has been increased; The drug resistance rate of four common gram-negative bacteria for amoxicillin was the highest with more than 90% and for cefuroxime above 60% and for cefoperazonesulbactam with the lowest resistant rate, which was sensitive to four common gram negative bacilli. In addition to Bauman Acinetobacter, other three kinds of bacteria.has high sensitivity to carbapenems, Amikacin, cefoxitin, ceftazidime and cefepime.Conclusions The widespread use or irrational use of antibacterial drugs can accelerate the rate of bacterial resistance, while the rational and standardized use of antimicrobial agents can help delay the development of bacterial resistance.Drug resistance of clinical isolated bacteria to antibiotics in our hospital is still not optimistic, in order to reduce hospital infection, we should strengthen the management of antimicrobial drug use.
王向党, 刘晓军, 鲁燕侠. 某医院抗菌药物的使用量与革兰阴性杆菌的耐药状况分析[J]. 武警医学, 2017, 28(7): 675-677.
WANG Xiangdang, LIU Xiaojun, and LU Yanxia. The consumption of antibiotics and the resistant situation of Gram negative bacteria in a BeijingTertiaryHospital. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(7): 675-677.
WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC Classification and DDD Assignment [M].13th ed.Norway:Norwegian InstPublHlth, 2009.
2017, Vol. 28 
