Meta-analysis of efficacy and safety of compound glycyrrhizin combined with minoxidil in the treatment of alopecia areata
LIU Jiyuan1,2, XU Haihuan1, LU Tao1
1.Department of Dermatology, Affiliated Hospital of Logistics University of Chinese People’s Armed Police Force, Tianjin 300162,China;
2. Hospital of Army 92765,Sanya 572021,China
Objective To systematically evaluate the efficacy and safety of compound glycyrrhizin combined with minoxidil in the treatment of alopecia areata.Methods Randomized controled trials were retrieved from PubMed, Cochrane library, EmBase, Wanfang database, Chinese journal full text database (CNKI) and the VP information resource system was used to observe the clinical efficacy of compound glycyrrhizin combined with minoxidil in the treatment of alopecia areata (randomized controlled trial, RCT). The retrieval covered the period between January 1979 and May 2018.The related literature was analyzed and evaluated. Statistical software RevMan 5.3 was used for the meta-analysis of the data.Results A total of 11 Chinese RCT articles were included, involving 1102 patients. The meta-analysis Results showed that there was statistically significant difference between the two groups in the effective rate [OR=3.86, 95% CI (2.83, 5.25, P<0.01)]and in the cure rate[OR=3.05, 95%CI (2.33, 3.99), P<0.01]. There was no significant difference in the incidence of adverse reactions between the two groups [OR=0.91, 95%CI(0.52, 1.58), P=0.73], but the difference in the incidence of irritant dermatitis was statistically significant between the two groups[OR=0.50, 95% CI (0.26, 0.96), P=0.04].Conclusions Compared with minoxidil treatment, compound glycyrrhizin combined with minoxidil has a better effect and a higher recovery rate in the treatment of alopecia areata, and the side effect is relatively light.
刘吉元, 徐海环, 卢涛. 复方甘草酸苷联合米诺地尔治疗斑秃有效性及安全性的Meta分析[J]. 武警医学, 2018, 29(10): 929-934.
LIU Jiyuan, XU Haihuan, LU Tao. Meta-analysis of efficacy and safety of compound glycyrrhizin combined with minoxidil in the treatment of alopecia areata. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(10): 929-934.
Strazzulla L C, Wang E H C, Avila L, et al. Alopecia areata : Disease characteristics, clinical evaluation, and new perspectives on pathogenesis [J]. J Am Acad Dermatol, 2018, 78(1): 1-12.
Iorizzo M, Oranje A P. Current and future treatments of alopecia areata and trichotillomania in children [J]. Expert Opin Pharmacother, 2016, 17(13): 1767-1773.
[7]
Hordinsky M, Donati A. Alopecia areata: an evidence-based treatment update [J]. Am J Clin Dermatol, 2014, 15(3): 231-246.
Kicinski M, Springate D A, Kontopantelis E. Publication bias in meta-analyses from the Cochrane Database of Systematic Reviews [J]. Stat Med, 2015, 34(20): 2781-2793.
Yang D, Zheng J, Zhang Y, et al. Total Glucosides of Paeony Capsule Plus Compound Glycyrrhizin Tablets for the Treatment of Severe Alopecia Areata in Children: A Randomized Controlled Trial[J]. Evid Based Complement Med, 2013(5): 1-5.
[24]
Gold R, Buttgereit F,Toyka K V. Mechanism of action of glucocorticosteroid hormones: possible implications for therapy of neuroimmunological disorders [J]. J Neuroimmunol, 2001, 117(1-2): 1-8.
[25]
Fujisawa Y, Sakamoto M, Matsushita M, et al. Glycyrrhizin inhibits the lytic pathway of complement — Possible mechanism of its anti-inflammatory effect on liver cells in viral hepatitis &mdash [J]. Microbiol Immunol, 2013, 44(9): 799-804.
Han J H, Kwon O S, Chung J H, et al. Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle [J]. J Dermatol Sci, 2004, 34(2): 91-98.
2018, Vol. 29 
